Table of Contents
Control
of gene expression
Two kinds of transcriptional control
Transcription of the lac operon
Regulatory gene: lacI
Regulator site:
Repression
Induction
Induction
Experimental evidence?
Mutant affecting repressor
Makes a defective repressor
Effect on a second lac operon?
Repressor works in trans
Effect of a defective operator?
Operator works in cis
Another form of negative control
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Author:
Philip Farabaugh
The
trp operon
Transcription of the trp genes
Translation of the trp proteins
Tryptophan causes repression
No operons in eukaryotes
Three GAL genes
GAL activator turns on all three
Other types of regulation
Antibody genes are rearranged
DNA segments are deleted
Alternative RNA splicing
Translational control
Different number of X chromosomes
Difference in X chromosome number
Mary Lyon discovers inactive X
Next time
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