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| Note: The reviews listed here are for
your reference. You are NOT REQUIRED to read them, but they
might prove useful if you did. |
| |
Date |
Readings |
Tu |
2/1/05 |
Review: Lee
TT, Young RA. 2000. Transcription of eukaryotic
protein-coding genes. Annu Rev Genet, 34:77-137. |
Th |
2/3/05 |
Review: Lee
TT, Young RA. 2000. Transcription of eukaryotic
protein-coding genes. Annu Rev Genet, 34:77-137. |
Tu |
2/8/05 |
Liao SM, Zhang
J, Jeffery DA, Koleske AJ, Thompson CM, Chao DM, Viljoen
M, van Vuuren HJ, Young RA.
A kinase-cyclin pair in the RNA polymerase II holoenzyme.
Nature. 1995 374:193-6. [Journal prompt] |
Th |
2/10/05 |
Review: Lee
TT, Young RA. 2000. Transcription of eukaryotic
protein-coding genes. Annu Rev Genet, 34:77-137. |
Tu |
2/15/05 |
Gaudreau,
L, Adam M, Ptashne M. 1998. Activation of
transcription in vitro by recruitment of the yeast
RNA polymerase II holoenzyme. Mol Cell 1:913-916.
Keaveney M, Struhl
K. 1998. Activator-mediated recruitment of the
RNA polymerase II machinery is the predominant mechanism
for transcriptional activation in yeast. Mol Cell
1:917-924.
Questions for in-class work
|
Th |
2/17/05 |
Relevant reviews (working
on Group Wiki Projects) |
|
|
Review: Felsenfeld
G, Groudine M. 2003. Controlling the double helix.
Nature. 421:448-53.
Review: Cosma
MP. Ordered recruitment: gene-specific mechanism
of transcription activation. Mol Cell. 2002 10:227-36. |
|
|
Relevant reviews (more
working
on Group Wiki Projects) |
Tu |
3/1/05 |
Gregory
PD, Schmid A, Zavari M, Munsterkotter M, Horz W.
Chromatin remodelling at the PHO8 promoter requires
SWI-SNF and SAGA at a step subsequent to activator
binding. EMBO J. 1999 18:6407-14.
Shang Y, Hu X, DiRenzo
J, Lazar MA, Brown M. Cofactor dynamics and sufficiency
in estrogen receptor-regulated transcription. Cell.
2000 103:843-52.
Soutoglou, E,
Talianidis I. 2002. Coordination of PIC assembly
and chromatin remodeling during differentiation-induced
gene activation. Science. 295:1901-1904.
Questions for
in-class work |
Th |
3/3/05 |
Review: Turner
BM. Cellular memory and the histone code. Cell.
2002 111:285-91.
Review: de
la Cruz X, Lois S, Sanchez-Molina S, Martinez-Balbas
MA. Do protein motifs read the histone code?
Bioessays. 2005 27:164-75.
Review: Cosgrove
MS, Boeke JD, Wolberger C. Regulated nucleosome
mobility and the histone code. Nat Struct Mol Biol.
2004 11:1037-43. |
Tu |
3/8/05 |
Hassan
AH, Prochasson P, Neely KE, Galasinski SC, Chandy
M, Carrozza MJ, Workman JL. Function and selectivity
of bromodomains in anchoring chromatin-modifying
complexes to promoter nucleosomes. Cell. 2002 111:369-79.
Agalioti
T, Chen G, Thanos D. Deciphering
the transcriptional histone acetylation code for a
human gene. Cell. 2002 111:381-92.
Questions for in-class
work
|
Th |
3/10/05 |
Review: Howe
KJ. RNA polymerase II conducts a symphony of pre-mRNA
processing activities. Biochim Biophys Acta. 2002 1577:308-24. |
Tu |
3/15/05 |
Komarnitsky
P, Cho EJ, Buratowski S. Different phosphorylated
forms of RNA polymerase II and associated mRNA processing
factors during transcription. Genes Dev. 2000 14:2452-60.
Meinhart A, Cramer
P. Recognition of RNA polymerase II carboxy-terminal
domain by 3'-RNA-processing factors.
Nature. 2004 430:223-6.
Questions for in-class work |
Th |
3/17/05 |
Midterm Examination |
Tu |
3/22/05 |
SPRING BREAK |
Th |
3/24/05 |
SPRING BREAK |
Tu |
3/29/05 |
None |
Th |
3/31/05 |
None |
|
|
Review: Preiss
T, W Hentze M. Starting the protein synthesis
machine: eukaryotic translation initiation. Bioessays.
2003 25:1201-1211.
|
Th |
4/7/05 |
Review: Preiss
T, W Hentze M. Starting the protein synthesis machine:
eukaryotic translation initiation. Bioessays. 2003
25:1201-1211. |
|
4/12/05 |
Fletcher
CM, Pestova TV, Hellen CU, Wagner G. Structure
and interactions of the translation initiation factor
eIF1. EMBO J. 1999 18:2631-2637.
Battiste JL, Pestova TV, Hellen CU, Wagner G.
The eIF1A solution structure reveals a large RNA-binding surface important for
scanning function.
Mol Cell. 2000 5:109-119.
Questions for in-class work
|
|
4/14/05 |
Review: Preiss
T, W Hentze M. Starting the protein synthesis machine:
eukaryotic translation initiation. Bioessays. 2003
25:1201-1211. |
|
4/19/05 |
Review: Hinnebusch
AG. Translational regulation of yeast GCN4. A
window on factors that control initiator-trna binding
to the ribosome. J Biol Chem. 1997 272:21661-4. |
|
4/21/05 |
Review: Sonenberg
N, Dever TE. Eukaryotic translation initiation
factors and regulators. Curr Opin Struct Biol. 2003
13:56-63. |
|
4/26/05 |
Vende P, Piron
M, Castagne N, Poncet D. Efficient translation
of rotavirus mRNA requires simultaneous interaction
of NSP3 with the eukaryotic translation initiation
factor eIF4G and the mRNA 3' end. J Virol. 2000 74:7064-7071.
Vitour D, Lindenbaum
P, Vende P, Becker MM, Poncet D. RoXaN, a novel
cellular protein containing TPR, LD, and zinc finger
motifs, forms a ternary complex with eukaryotic initiation
factor 4G and rotavirus NSP3. J Virol. 2004 78:3851-3862.
Questions for in-class
work |
|
4/28/05 |
Review: Hellen
CU, Sarnow P. Internal ribosome entry sites in
eukaryotic mRNA molecules. Genes Dev. 2001 15:1593-612.
Review: Bushell
M, Sarnow P. Hijacking the translation apparatus
by RNA viruses. J Cell Biol. 2002 158:395-399.
Review: Komar
AA, Hatzoglou M. Internal ribosome entry sites in cellular mRNAs:
The mystery of their existence.
J Biol Chem. 2005 [Epub ahead of print] |
|
5/3/05 |
Jan E, Sarnow
P. Factorless ribosome assembly on the internal
ribosome entry site of cricket paralysis virus. J Mol
Biol. 2002 324:889-902.
Fernandez J, Yaman
I, Huang C, Liu H, Lopez AB, Komar AA, Caprara MG,
Merrick WC, Snider MD, Kaufman RJ, Lamers WH, Hatzoglou
M. Ribosome stalling regulates IRES-mediated
translation in eukaryotes, a parallel to prokaryotic
attenuation. Mol Cell. 2005 17:405-416.
Questions for in-class
work |
|
5/5/05 |
Review: Gebauer
F, Hentze MW. Molecular mechanisms of translational
control. Nat Rev Mol Cell Biol. 2004 5:827-835.
Review: Lasko
P. Cup-ling oskar RNA localization and translational
control. J Cell Biol. 2003 163:1189-91. |
|
5/10/05 |
Muckenthaler
M, Gray NK, Hentze MW. IRP-1 binding to ferritin
mRNA prevents the recruitment of the small ribosomal
subunit by the cap-binding complex eIF4F. Mol Cell.
1998 2:383-388.
Gebauer F, Grskovic
M, Hentze MW. Drosophila sex-lethal
inhibits the stable association of the 40S ribosomal
subunit with msl-2 mRNA. Mol Cell. 2003 11:1397-1404.
Nakamura A, Sato K, Hanyu-Nakamura K.
Drosophila cup is an eIF4E binding protein that associates with Bruno
and regulates oskar mRNA translation in oogenesis. Dev Cell. 2004 6:69-78.
Questions for in-class work |
|
5/12/05 |
None |
|
5/17/05 |
Final Examination |
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