introductory course describing the essential principles of biochemistry.
Topics include the structure and characterization of biological
macromolecules, the energetics and thermodynamics of coupled biological
reactions, and enzymology. The most important metabolic pathways
are described, emphasizing their cellular compartmentalization,
integration and control. (Fall) Prerequisites: BIOL 100 and CHEM
352. Recommended: BIOL 303. Note: Also listed as CHEM 430.
Laboratory Projects in Biological Sciences
This course is primarily for graduate students at the M.S. level.
It is designed to increase the student's familiarity with modern
experimental techniques employed in the biological sciences. Students
will be assigned to individually supervised laboratory projects.
A detailed account of the progress of the project will be required.
Tutorial Projects in Biological Sciences
Independent studies to be carried out by graduate students under
the supervision of a faculty member. Prerequisite: Consent of instructor.
to Laboratory/Field Research
The purpose of this course is to introduce incoming graduate students
to the breadth of possible research areas at UMBC. A student taking
this course will do research for roughly half a regular semester
in each of two or three professors' laboratories. This will provide
the student with an acquaintance with laboratory techniques and
faculty members in several areas before making a decision on his
or her thesis advisor. One credit is earned per laboratory.
Topics in Comparative Animal Physiology
This course takes a comparative approach to the study of how various
selective pressures have resulted in the evolution of specific solutions
to physiological problems. These solutions are viewed within the
context of the fundamental limitations to biological evolution that
are set by the physical and chemical properties of matter. The exact
topic will change from semester to semester. Representative topics
might include vision, temperature regulation and thermal tolerance,
renal physiology, or cognitive neurophysiology. Most of the material
covered will be from original research reports that will be evaluated
critically by each student. Prerequisite: Permission of the instructor.
of Municipal Aquaria
This course will focus on the organization and operation of aquaria
and aquaculture facilities. The scientific and practical criteria
used to select the mammals, fish, and invertebrates displayed at
aquaria or the species grown commercially by aquaculture methods
will be described, as will the taxonomy, ecology, population dynamics,
collection methods, transportation, nutrition, methods of handling,
and health maintenance of those species. Finally, the roles and
missions of such facilities will be discussed, with particular attention
to aquaria. This segment of the course will demonstrate how marketing
and visitors' services as well as programs in education and research
are used to meet civic responsibilities and public concerns.
The combined approaches of bacterial genetics, molecular biology
and biochemistry are applied to the study of bacterial physiological
processes. An emphasis is placed on examining adaptation strategies
used by bacteria upon encountering alterations in environment. Topics
include mechanisms of transcriptional and pos translational control,
regulation of carbon and nitrogen metabolism, biosynthesis, energy
transduction, signal transduction systems, and bacterial development,
Prerequisites: BIOL 302 and BIOL 303 or consent of instructor. BI0L
430 or CHEM 437 is recommended.
Genetics and molecular biology of lower and higher eukaryotes and
their viruses. The course will focus on the maintenance and expression
of genetic material as it relates to cell growth and development.
It will cover current topics in the molecular genetics of several
lower and higher eukaryotes at an advanced level, including mechanisms
of genetic control that operate at the level of DNA replication,
transcription, and translation. Topics to include the molecular
basis of phenomena such as gene amplification, global control of
transcription initiation, protein sorting and secretion, control
of yeast mating type as a model for development, the origin of antigen
diversity, oncogenesis, pattern formation in Drosophila, sex determination
in mammals. (Fall)Prerequisites: BIOL 302 and BIOL 303 or consent
A course designed to cover major topics in cytology and cytogenetics.
Half lecture/seminar, half laboratory. The lecture material includes
such topics as chromosome structure, rearranged chromosomes, aneuploidy,
and supernumerary chromosomes, and chromosome behavior during meiosis.
Prerequisites: BIOL 302, 302L, and 303 or permission of instructor.
Topics in Cell Biology
A course designed to acquaint graduate students with contemporary
problems of structure and function at the cellular level through
a critical examination of the current literature. The course will
include both lecture material, with an emphasis on the experimental
basis of current knowledge, and presentations by students of oral
and written reports on selected topics. The area covered in any
semester will vary according to recent developments in the field
and according to the interests of the students and faculty. The
list of available areas includes: structure and function of biomembranes;
composition, structure, and replication of chromosomes; assembly,
growth, and reproduction of cytoplasmic organelles; cellular growth
and division; regulation of cellular function; nuclear-cytoplasmic
interactions. May be repeated for credit. Prerequisite: BIOL 303,
and/or consent of the instructor.
Theory and practice of the study of biological materials with the
high resolution of electron microscope. Specimens will be prepared
for examination by a variety of modern procedures. These include:
tissue and cell fixation, embedding for ultrathin sectioning; carbon
film preparation, mounting of particulate materials and macromolecules;
positive and negative staining; metal shadowing in the vacuum evaporator;
critical point drying. An introduction to scanning electron microscopy
will be provided. The photographic darkroom procedures required
for the production of finished electron micrographs are included.
Prerequisites: BIOL 303 and/or the consent of the instructor.
and Function of Animal Tissues
Function and microscopic anatomy of major vertebrate organ systems.
Emphasis on correlation of structure and function, particularly
at the level of the cell and tissue. Topics presented include: integumentary,
digestive, urinary, respiratory, circulatory, endocrine, reproductive,
and immune systems. Prerequisites: BIOL 303, BIOL 303L and CHEM
in Animal Tissue Structure
This laboratory is designed to provide the advanced student with
an intensive understanding of the structure of cells and tissues.
Prepared slides of tissues are used to supplement and illustrate
the materials presented in BIOL 424. Emphasis is placed in recognition
of cell and tissue types. Drawing of cells and tissues is required.
Prerequisite or concurrent: BIOL 424.
This course will pursue in depth the rapidly expanding areas of
cellular, humoral, and tumor immunology. Following a brief overview
of the immune system's response to exogenous antigen, the course
will concentrate on such topics as: antibody production, structure,
and gene organization; lymphocyte subpopulations; cell-cell interactions;
cell-mediated immune responses; cell surface alloantigens; histocompatibility;
immunogenetics; transplantation and tumor immunology. The exact
content of the course will vary from year to year depending on the
status of research in the field. Prerequisites: BIOL 302 and BIOL
303, or consent of the instructor; BIOL 430 is recommended.
BIOL426 for APMB
to Molecular Biology
This course will focus on the molecular biology of eukaryotic cells
and will include such topics as the sequence organization of DNA
and genes, chromosome structure, messenger RNA synthesis and processing,
messenger RNA translation, and the regulation of the expression
of genetic information. Prerequisites: BIOL 302 and BIOL 303, or
consent of the instructor.
Applications in Molecular Biology
This course is designed as an introduction for biology and biochemistry
students to the use of applications software in the analysis of
DNA, RNA, and protein sequence data. The course will be taught in
a lab/lecture format with 2 lecture hours and 4 lab hours per week.
Topics will include operating systems, telecommunications with off-campus
databases, specific software packages for general and analytical
treatment of DNA, RNA, and protein sequence data. Some elementary
programming will be included. Prerequisites: BIOL 302 and BIOL 303.