CHARLES J. BIEBERICH
Ph.D. Johns Hopkins University, 1987
Postdoctoral, Yale University
FAX (410) 455-3875; Voice (410) 455-3125
The central theme of my research
program is to use transgenic approaches to study how genes function in developmental
pathways and to apply that knowledge to the elucidation of human disease
mechanisms. As the molecular dissection of development and disease proceeds,
it becomes clear that disease often represents altered development.
A major focus of research in my laboratory is to determine the developmental
functions of a family of transcription factors encoded by the Hox genes.
By changing the patterns of expression of Hox genes in transgenic mice,
we have begun to dissect their functions during embryogenesis. These
studies have revealed that altering the expression of a Hox gene can induce
congenital malformations similar to those that afflict human newborns.
A second focus of my laboratory is to study the molecular basis of organogenesis,
using the prostate gland as a model system. Although the prostate
gland is the most disease-prone organ in the human body, the molecular basis
of its development is poorly understood. We have characterized two prostate-specific
transcription factors, and are studying their roles in prostate differentiation.
Genomic approaches are also being applied to characterize the genetic pathways
that dictate prostate organogenesis. Understanding these developmental
processes will facilitate the elucidation of human prostate disease mechanisms.
Dai B., Kim O., Xie Y., Guo Z., Xu K., Wang B., Kong X., Melamed J.,
Chen H., Bieberich CJ., Borowsky AD., Kung HJ., Wei G., Ostrowski MC.,
Y. (2006). Tyrosine kinase Etk/BMX Is up-regulated in human prostate
cancer and its overexpression induces prostate intraepithelial neoplasia
Cancer Res. 66:8058-8064. (Abstract)
Li X., Guan B., Maghami S., and Bieberich CJ. (2006). NKX3.1 is regulated
by protein kinase CK2 in prostate tumor cells. Mol. Cell Biol. 26:3008-3017.
:Chen H., Mutton LN., Prins GS., and Bieberich CJ. (2005). Distinct
regulatory elements mediate the dynamic expression pattern of Nkx3.1. Dev.
Dyn. 234:961-973. (Abstract)
: Chen H., and Bieberich CJ. (2005). Structural and functional analysis
of domains mediating interaction between NKX-3.1 and PDEF. J. Cell. Biochem.
Wubah J.A., Fischer C.M., Rolfzen L.N., Khalili M., Kang J., Green JE.,
and Bieberich C.J. (2002). Ventral prostate predominant l, a novel mouse
gene expressed exclusively in the prostate. Prostate.51:21-9.
Chen H., Nandi A.K., Li X., and Bieberich C.J. (2002). NKX-3.1 interacts
with prostate-derived Ets factor and regulates the activity of the PSA
promoter. Cancer Res. 62:338-40. (Abstract)
Prins, G., Birch, L., Habermann,
H., Chang, W., Tebeau, C., Putz, O., and Bieberich, C. (2001). Influence
of neonatal estrogens on mature prostate function. Reprod. Fertil.
Sreenath, T., Orosz, A.,
and Bieberich, C. J. 1999. Androgen-independent expression of hoxb-13
mouse prostate. The Prostate 41: 203-207. (Abstract)
Bieberich, C. J., Fujita,
K., He, W.-W., and Jay, G. 1996. Prostate-specific and
androgen dependent expression of a novel homeobox gene. J.
Sreenath, T. L., Pollock,
R. A., and Bieberich, C. J. 1996. Functional specificity
of Hoxa-4 in vertebral patterning lies outside of the homeodomain.
Proc. Natl. Acad. Sci. USA 93:9636-9640. (Abstract)
Pollock, R.A., Sreenath,
T., Ngo, L., and Bieberich, C.J. 1995. Gain of function
mutations for paralogous Hox genes: Implications for the evolution
of Hox gene function. Proc. Natl. Acad. Sci. USA 92:4492-4497.