| Molecular Biology
and Genetics seek to understand how the molecules that make
up cells determine the behavior of living things. Biologists
use molecular and genetic tools to study the function of
those molecules in the complex milieu of the living cell.
Groups in our department are using these approaches to study
a wide variety of questions, including the fundamental processes
of transcription and translation, mechanisms of global gene
control including signal transduction pathways, the function
of the visual and olfactory systems, and the nature of genetic
diversity in natural populations and how that affects their
evolution, among others. The systems under study cover the
range of model organisms (bacteria, yeast, slime molds, worms,
fruit flies, zebrafish, and mice) though the results of these
studies relate directly or indirectly to human health.
Farabaugh, Philip
Molecular genetics of translational accuracy in the yeast Saccharomyces cerevisiae and bacterium Escherichia coli Mendelson, Tamra
Molecular phylogenetic systematics; phylogenetic reconstruction of gene families Zengel, Janice
Genetic, biochemical, and phylogenetic approaches to understanding the synthesis, structure, and function of ribosomes in bacteria and yeast Miller, Stephen
Identification and characterization of transposons for tagging important developmental loci in Volvox carteri Craig, Nessly
Mechanism of mammalian ribosomal RNA synthesis and its regulation. Lu, Hua
Forward and reverse genetics to identify novel defense genes; functional characterization of defense genes in regulating disease resistance in plants. Lindahl, Lasse
Genetic, biochemical, and phylogenetic approaches to understanding the synthesis, structure, and function of ribosomes in bacteria and yeast. Freeland, Stephen
We study the theory of synthetic gene design (i.e. how best to encode a specific protein sequence in DNA). For this work we collaborate extensively with "wet labs" Wolf, Jr., Richard E.
Investigation of a new mechanism of transcription activation in the bacterium E. coli and investigation of a new mechanism of induction. Eisenmann, David
We study the role of the Wnt signaling pathway in controlling cell fate decisions during C. elegans development. We also study regulation and function of the Hox gene lin-39 in C. elegans. Schreier, Harold
Molecular microbial ecology, physiology and genetics Robinson, Phyllis
My research program uses the techniques of molecular biology to explore structure function relationships of visual pigments. Blumberg, Daphne
We use the methods of Molecular Biology and Genetics to identify and study genes involved in cell fate specification and developmental morphogenesis Leips, Jeff
Genetic mapping of quantitative traits, association mapping to identify the effects of natural polymorphism in candidate genes on phenotypic variation Bieberich, Charles
We are developing new transgenic mouse models of human prostate cancer. Brewster, Rachel
Investigation of molecular mechanisms and genetic pathways underlying neural tube morphogenesis. Ostrand-Rosenberg, Suzanne
Tumor immunology; molecular and genetic regulation of tumor-induced immunosuppressive cells Bustos, Mauricio
We investigate the role of ubiquitin/proteasome mediated protein degradation in transcription and the regulation of gene expression in eukaryotes Erill, Ivan
Cross-linking between experimental assays and in-silico data for regulatory elements. |
