A number of faculty members have programs that
center on the mode of action of, and detection of, toxicants and
entities relevant to homeland security. These efforts focus on
the several general areas. Projects centered on analytical methodologies
include development of new methods of detection of toxins, pollutants
and their metabolites in environmental and biological matrices
and the development of nanomaterials and fabrication of nanostructures
and associated techniques for ultra-sensitive detection of toxins,
explosives and metabolites intracellularly and in complex matrices.
Groups also work on molecular aspects of these problems including
study of the organic chemistry of toxins, particularly carcinogens,
their mechanisms of toxication and molecular defenses against
toxin assault. These studies entail generation and characterization
of reactive intermediates derived from toxic agents and the DNA
adducts derived from carcinogens. There are also efforts to generate
structure-activity relationships among toxins and anti-toxins.
Reactive intermediates derived from carcinogens. Structure of DNA adducts derived from reactions of alkylating agents.
Development of novel methods for the determination of biomarkers for licit and illicit drugs.