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Elsa Garcin
Assistant Professor
Post-Doctoral The Scripps Research Institute, La Jolla (CA) 1999; Ph.D. Universite Joseph Fourier, Grenoble (France) 1998; M.S. Universite Joseph Fourier, Grenoble (France) 1994
Visit the Garcin Lab Homepage:  Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ “Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer” J. Biol. Chem. 285 (5), (2010), 3064-3075. PMC2823414 Elsa Garcin, 'La clé vers de nouveaux inhibiteurs (A novel strategy to design iNOS specific inhibitors)' Médecines Sciences, 25 (2009), 562-564. Nature Research Highlights
Garcin E.D., Arvai, A.S., Rosenfeld R.J., Kroeger, M.D., Crane, B.R., Andersson G., Andrews A., Hamley P.J., Mallinder P.R., Nicholls D.J., St-Gallay S.A., Tinker A.C., Gensmantel N.P., Mete A., Cheshire D.R., Connolly S., Stuehr D.J., Aberg A., Wallace A.V., Tainer J.A., Getzoff E.D. 'Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.' Nat. Chem. Biol. 4 (2008), 700-707. Published online: 12 October 2008; |doi:10.1038/nchembio.115
Garcin E.D., Hosfield D.J., Haas B.J.,Björas M., Cunningham R., Tainer J.A. 'DNA apurinic/apyrimidinic site binding and excision by endonuclease IV' Nat. Struct. Mol. Biol. 15 (5), (2008), 515-522. Rameau G.A., Tukey D.S., Garcin-Hosfield E.D., Misra C., Titcombe R.F., Khatri L., Getzoff E.D., Ziff E.B. 'Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor induces AMPA receptor trafficking and neuronal cell death.' J. Neurosciences 27 (13), 3445-3455 (2007) Panda K., Haque M.M., Garcin-Hosfield E.D., Durra D., Getzoff E.D., Stuehr D.J. 'Surface charge interactions of electron transport modules govern catalysis by nitric oxide synthase.' J. Biol. Chem. 281(48), 36819-36827 (2006). Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. 'C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric oxide synthase.' J. Biol. Chem. 280(47), 39208-39219 (2005). Garcin E.D., Bruns C.M., Lloyd S.J., Hosfield D.J., Tiso M., Gachhui R., Stuehr D., Tainer J.A. and Getzoff E.D. 'Structural Basis for isozyme-specific regulation of electron transfer in Nitric Oxide Synthase.' J. Biol. Chem. 279(36), 37918-27 (2004). Rosenfeld R.J., Garcin E.D., Panda K., Andersson G., Aberg A., Wallace A.V., Morris G.M., Olson A.J., Stuehr D.J., Tainer J.A. and Getzoff E.D. 'Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency. 'Biochemistry 41 (47), 13915-13925 (2002). E. Garcin, X. Vernede, C. Hatchikian, A. Volbeda, M. Frey, J.-C. Fontecilla-Camps 'The Crystal Structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center.' Structure 7(5), 557-566 (1999).
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