|
Katherine Seley-Radtke
Professor
Post-Doctoral Auburn University 1996; Ph.D. Auburn University 1996; B.A. University of South Florida 1992
Zimmermann, S. C.; Sadler, J. M.; Graciela Andrei, Robert Snoeck, Balzarini, J.; Seley-Radtke, K. L. 'Carbocyclic 5'-Nor 'Reverse' Fleximers. Design, Synthesis and Preliminary Biological Activity', MedChemComm in press.
Novikov, M.S.; Buckheit, R.; Temburnikar, K.; Khandazhinskaya, A. L.; Ivanov, A.V; Seley-Radtke, K.L.; “1-Benzyl derivatives of 5-(arylamino)uracils as potential anti-HIV-1 and EBV agents' Bioorg Med Chem 2010, 18, 8310-14.
Wauchope, O. R.; Tomney, M. J.; Pepper, J. L.; Korba, B. E.; Seley-Radtke, K. L. 2'-C-Modified tricyclic nucleosides as potential anti-HCV therapeutics, Org Lett 2010, 12, 4466-4469.
Matyugina, E. S.; Seley-Radtke, K. L.; Andronova, V. L.; Galegov, G. A.; Khandazhinskaya, A. L. Synthesis and antiviral evaluation against vaccinia virus of new N1-oxide analogues of 5’-noraristeromycin, Russian J Bioorg Chem 2010, 36, 730-733; Original Russian Text: Bioorganicheskaya Khimiya, 2010, 797–801.
Tomney, M.; Korba, B.; Zimmermann, S.; Seley-Radtke, K. L. “Synthesis of a Series of 2’-Modified Tricyclic Nucleosides as Potential Anti-HCV Agents” Antiviral Res. 2010, 86, A68.
Sadler, J. M.; Mosley, S. L.; Dorgan, K. M.; Zhou, Z. S.; Seley-Radtke, K. L. 'Synthetic Strategies Toward Carbocyclic Purine-Pyrimidine Hybrid Nucleoside Inhibitors' Bioorg. Med. Chem., 2009, 17, 5520-5525.
Ivanov, A.; Tunitskaya, V.; Smirnova, O.; Buckheit, R.; Seley-Radtke, K. L.; Ivanov, A.; Novikov, M. “Synthesis and Antiviral Activity of Substituted Uracils” Antiviral Res. 2009, 82, A58.
Seley-Radtke, K. L.; Sunkara, N. K. 'Carbocyclic Thymidine Analogues as Potential Antiviral Agents' Nucleosides, Nucleotides, Nucleic Acids 2009, 28, 633-641.
O'Daniel, P. I.; Jefferson, M.; Wiest, O.; Seley-Radtke, K. L. 'Computational Studies of Expanded Heterocyclic Nucleosides in DNA' J Biomol Struct Dyn, 2008, 3, 283-292. (Cover)
Zhang, Z.; Wauchope, O. R.; Seley-Radtke, K. L. 'Design, Synthesis and Mechanistic Studies of a Series of Expanded Xanthosine Nucleosides' Tetrahedron 2008, 64, 10791-10797.
Sadler, J. M.; Ojewoye, O.; Seley-Radtke, K. L. ''Reverse Fleximers.' Introduction of a series of 5-substituted Carbocyclic uridine analogues' Nucleic Acids Symp Ser. 2008, 52, 571-572.
Seley-Radtke, K. L.; Zhang, Z.; Wauchope, O. R.; Zimmermann, S. C.; Ivanov, A.; Korba, B. 'Hetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity' Nucleic Acids Symp Ser. 2008, 52, 635-636.
Mosley, S. L.; Bakke, B. A.; Sadler, J. M.; Dorgan, K.; Zhou, Z. S.; Seley-Radtke, K. L. 'Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase', Bioorganic Med. Chem. 2006 14, 7967-7971.
Sunkara, N. K.; Mosley, S. L.; Seley-Radtke, K. L. 'A Carbocyclic 7-Deaza Purine-Pyrimidine Hybrid Nucleoside' Collect. Czech. Chem. Commun., 2006, 71, 1161-1168.
Quirk, S.; Seley-Radtke, K.L. 'Purification, crystallization, & preliminary X-ray characterization of human GTP fucose pyrophosphorylase' Acta Cryst. 2006, F62, 392-394.
Quirk, S.; Seley, K. L. 'Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site' Biochem. 2005,44, 13172-13178.
Quirk, S.; Seley, K. L. 'Substrate discrimination by human GTP-fucose pyrophosphorylase' Biochem. 2005, 44, 10854-10863.
Seley, K. L.; Salim, S.; Zhang, L.; O’Daniel, P. I. “Molecular Chameleons'. Design and Synthesis of A New Series of Flexible Nucleosides' J. Org. Chem. 2005, 70, 1612-1619.
Seley, K. L.; Salim, S.; Zhang, L.;'Molecular Chameleons'. Design and Synthesis of C-4-Substituted Imidazole Fleximers Org, Lett. 2005, 7, 63-66.
Schwimmer, L. J.; Rohatgi, P.; Azizi, B.; Seley, K. L.; Doyle, D. F. 'Creation and Discovery of Ligand-Receptor Pairs for Small Molecule Control of Transcription' Proc. Nat. Acad. Sci. 2004, 101, 14707-14712.
Polak, M.; Seley, K. L.; Plavec, J. 'Conformational Properties of Novel Shaped Nucleosides – Fleximers' J. Am. Chem. Soc. 2004, 126, 8159-8166.
Wallace, L. J. M.; Candlish, D.; Hagos, A.; Seley, K. L.; de Koning, H. P. 'Selective Transport of a New Class of Purine Antimetabolites by the Protozoan Parasite Trypanosoma Brucei' Nucleosides, Nucleotides, Nucleic Acids 2004, 23, 1441-1444.
Seley, K. L.; Mosley, S. L.; Xing, F. 'Carbocyclic Isoadenosine Analogues of Neplanocin A' Org. Letters, 2003, 5, 4401-4403.
Seley, K. L.; O'Daniel, P. I.; Salim, S. 'Design and Synthesis of a Series of Chlorinated 3-Deazaadenine Derivatives' Nucleosides, Nucleotides, Nucleic Acids, 2003, 22, 2133-2144.
Seley, K. L.; Quirk, S.; Salim, S.; Zhang, L.; Hagos, A. 'Unexpected Inhibition of S-Adenosyl-L-homocysteine Hydrolase by a Guanosine Nucleoside' Bioorg. Med. Chem. Lett. 2003, 13, 1985-1988.
Seley, K. L.; Zhang, L.; Hagos, A.; Quirk, S. ''Fleximers'. Design and Synthesis of A New Class of Novel Shape-Modified Nucleosides' J. Org. Chem., 2002, 67, 3365-3373.
Seley, K. L.; Zhang, L. Hagos, A. ''Fleximers'. Design and Synthesis of Two Novel Split Nucleosides' Org. Letters, 2001, 3, 3209-3210.
Seley, K. L.; Januszczyk, P.; Hagos, A.; Zhang, L.; Dransfield, D.T. 'Synthesis and Antitumor Activity of Thieno-Separated Tricyclic Purines' J. Med. Chem., 2000, 43, 4877-4883.
|
