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CONTACT INFORMATION
Office: CHEM 405C
Phone: 410-455-8684
Professional Interests
Publications
Honors/Awards
Funding
Courses Taught
Research Group
Katherine Seley-Radtke
Professor
Post-Doctoral Auburn University 1996; Ph.D. Auburn University 1996; B.A. University of South Florida 1992
SELECTED PUBLICATIONS

Temburnikar, K.; Brace, Seley-Radtke, K. L.'Synthesis of 2'-deoxy-9-deaza-C-nucleosides using Heck methodology', J Org Chem, 2013, 78, 7305-7311.

 

Matyugina, E. S.; Valuev-Elliston, V. T.; Gaysman, A.; Novikov, M. S.; Chizhov, A. O.; Kochetkov, S. N.; Seley-Radtke, K. L.; Khandazinskaya, A. L. 'Structure-Activity Evaluation of New Uracil-Containing Non-Nucleoside Inhibitors of HIV Reverse Transcriptase' MedChemComm, 2013, 4, 1443 – 1451.

Novikov, M. S.; Babkov, D. A.; Paramonova, M. P.; Ozerov, A. A.; Khandazhinskaya, A. L.; Andrei, G.; Snoeck, R.; Balzarini, J.; Seley-Radtke, K. L.  'Synthesis and anti-HCMV activity of 1-[w-(phenoxy)pentyl]uracil derivatives and analogues thereof' Bioorg Med Chem 2013, 21, 4151-4157.

 

Matyugina, E. S.; Valuev-Elliston, V.; Babkov, D.; Novikov, M.; Ivanov, A.; Kutchetkov, S.; Balzarini, J.; Seley-Radtke, K. L.; Khandazhinskaya, A. L. '5'-nor carbocyclic nucleosides: surprising nonnucleoside inhibitors of HIV-1 reverse transcriptase', MedChemComm, 2013, 4, 741-748.

Zimmermann, S. C.; Sadler, J. M.; O' Daniel, P. I.; Kim, Nathaniel T.; Seley-Radtke, K. L. ' “Reverse” Carbocyclic Fleximers. Synthesis of a New Class of Adenosine Deaminase Inhibitors' Nucleosides, Nucleotides & Nucleic Acids, 2013, 32, 137-154.

Novikov, M. S., Paramonova; M. P., Babkov, D. A., Valuev-Elliston, V. T., Gavryushov, S. A. Ivanov, A. V., Kochetkov, S. N., Pannecouque, C., Andrei, G., Snoeck, R., Balzarini, J., Seley-Radtke, K. L. 'N1, N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase', Bioorg Med Chem, 2013, 21, 1150-1158.

Novikov, M. S. ; Babkova, D. A.; Paramonova, M. P.; Chizov, A. O., Seley-Radtke, K. L. 'A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides', Tetrahedron Letters, 2013, 54, 576-578.

Wauchope, O. R.; Velasquez, M.; Seley-Radtke, K. L. 'Synthetic routes to a series of proximal and distal 2'-deoxy nucleoside analogues.' Synthesis, 2012, 3496-3504.

 

Wauchope, O. R.; Johnson, C.; Krishnamurthy, P.; Andrei, G.; Snoeck, R.; Balzarini, J.; Seley-Radtke, K. L. 'Synthesis and biological evaluation of a series of thiophene-expanded purine 2'-deoxy nucleoside analogues.' Bioorg Med Chem, 2012 20, 3009-3015.

Temburnikar, K.; Zhang, Z.; Seley-Radtke, K. L.: 'Modified Synthesis of 3'-OTBDPS-Protected Furanoid Glycal”, Nucleosides, Nucleotides and Nucleic Acids, 2012 31, 319-327.

Manvilla, B. A.; Wauchope, O.; Seley-Radtke, K. L., Drohat, A. C.; 'NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1', Biochemistry 2011 50,10540-9.

Novikov, M.S.; Ivanova, O. N.; Ivanov, A.V.; Ozerov, A.A.; Valuev-Elliston, V. T.; Temburnikar, K.; Gurskaya, G. V.; Kochetkov, S. N.; Pannecouque, C.; Balzarini, J.; Seley-Radtke, K.L.; '1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents” Bioorg Med Chem 2011, 19, 5794-5802.

Zimmermann, S. C.; Sadler, J. M.; Andrei, G.; Snoeck, R.; Balzarini, J.; Seley-Radtke, K. L. 'Carbocyclic 5'-Nor 'Reverse' Fleximers. Design, Synthesis and Preliminary Biological Activity', MedChemComm 2011, 2, 650 - 654.

 

Novikov, M.S.; Buckheit, R.; Temburnikar, K.; Khandazhinskaya, A. L.; Ivanov, A.V; Seley-Radtke, K.L.; “1-Benzyl derivatives of 5-(arylamino)uracils as potential anti-HIV-1 and EBV agents' Bioorg Med Chem 2010, 18, 8310-14.

Wauchope, O. R.; Tomney, M. J.; Pepper, J. L.; Korba, B. E.; Seley-Radtke, K. L. 2'-C-Modified tricyclic nucleosides as potential anti-HCV therapeutics, Org Lett 2010, 12, 4466-4469.

Matyugina, E. S.; Seley-Radtke, K. L.; Andronova, V. L.; Galegov, G. A.; Khandazhinskaya, A. L. Synthesis and antiviral evaluation against vaccinia virus of new N1-oxide analogues of 5’-noraristeromycin, Russian J Bioorg Chem 2010, 36, 730-733; Original Russian Text: Bioorganicheskaya Khimiya, 2010, 797–801.

Tomney, M.; Korba, B.; Zimmermann, S.; Seley-Radtke, K. L. “Synthesis of a Series of 2’-Modified Tricyclic Nucleosides as Potential Anti-HCV Agents” Antiviral Res. 2010, 86, A68.

Sadler, J. M.; Mosley, S. L.; Dorgan, K. M.; Zhou, Z. S.; Seley-Radtke, K. L. 'Synthetic Strategies Toward Carbocyclic Purine-Pyrimidine Hybrid Nucleoside Inhibitors' Bioorg. Med. Chem., 2009, 17, 5520-5525.

Ivanov, A.; Tunitskaya, V.; Smirnova, O.; Buckheit, R.; Seley-Radtke, K. L.; Ivanov, A.; Novikov, M. “Synthesis and Antiviral Activity of Substituted Uracils” Antiviral Res. 2009, 82, A58.

Seley-Radtke, K. L.; Sunkara, N. K. 'Carbocyclic Thymidine Analogues as Potential Antiviral Agents' Nucleosides, Nucleotides, Nucleic Acids  2009, 28, 633-641.

O'Daniel, P. I.; Jefferson, M.; Wiest, O.; Seley-Radtke, K. L. 'Computational Studies of Expanded Heterocyclic Nucleosides in DNA' J Biomol Struct Dyn, 2008, 3, 283-292. (Cover)

Zhang, Z.; Wauchope, O. R.; Seley-Radtke, K. L.  'Design, Synthesis and Mechanistic Studies of a Series of Expanded Xanthosine Nucleosides' Tetrahedron 2008, 64, 10791-10797.

Sadler, J. M.; Ojewoye, O.; Seley-Radtke, K. L. ''Reverse Fleximers.' Introduction of a series of 5-substituted Carbocyclic uridine analogues' Nucleic Acids Symp Ser. 2008, 52, 571-572.

Seley-Radtke, K. L.; Zhang, Z.; Wauchope, O. R.; Zimmermann, S. C.; Ivanov, A.; Korba, B. 'Hetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity' Nucleic Acids Symp Ser. 2008, 52, 635-636.

Mosley, S. L.; Bakke, B. A.; Sadler, J. M.; Dorgan, K.; Zhou, Z. S.; Seley-Radtke, K. L.  'Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase', Bioorganic Med. Chem. 2006 14, 7967-7971.

Sunkara, N. K.; Mosley, S. L.; Seley-Radtke, K. L. 'A Carbocyclic 7-Deaza Purine-Pyrimidine Hybrid Nucleoside' Collect. Czech. Chem. Commun., 2006, 71, 1161-1168.

Quirk, S.; Seley-Radtke, K.L. 'Purification, crystallization, & preliminary X-ray characterization of human GTP fucose pyrophosphorylase' Acta Cryst. 2006, F62, 392-394.

Quirk, S.; Seley, K. L. 'Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site' Biochem. 2005,44, 13172-13178.

Quirk, S.; Seley, K. L. 'Substrate discrimination by human GTP-fucose pyrophosphorylase' Biochem. 2005, 44, 10854-10863.

Seley, K. L.; Salim, S.; Zhang, L.; O’Daniel, P. I. “Molecular Chameleons'. Design and Synthesis of A New Series of Flexible Nucleosides' J. Org. Chem. 2005, 70, 1612-1619.

Seley, K. L.; Salim, S.; Zhang, L.;'Molecular Chameleons'. Design and Synthesis of C-4-Substituted Imidazole Fleximers Org, Lett. 2005, 7, 63-66.

Schwimmer,  L. J.; Rohatgi, P.; Azizi, B.; Seley, K. L.; Doyle, D. F. 'Creation and Discovery of Ligand-Receptor Pairs for Small Molecule Control of Transcription' Proc. Nat. Acad. Sci. 2004, 101, 14707-14712.

Polak, M.; Seley, K. L.; Plavec, J. 'Conformational Properties of Novel Shaped Nucleosides – Fleximers' J. Am. Chem. Soc. 2004, 126, 8159-8166.

Wallace, L. J. M.; Candlish, D.; Hagos, A.; Seley, K. L.; de Koning, H. P. 'Selective Transport of a New Class of Purine Antimetabolites by the Protozoan Parasite Trypanosoma Brucei' Nucleosides, Nucleotides, Nucleic Acids  2004, 23, 1441-1444.

Seley, K. L.; Mosley, S. L.; Xing, F. 'Carbocyclic Isoadenosine Analogues of Neplanocin A' Org. Letters, 2003, 5, 4401-4403.

Seley, K. L.; O'Daniel, P. I.; Salim, S. 'Design and Synthesis of a Series of Chlorinated 3-Deazaadenine Derivatives' Nucleosides, Nucleotides, Nucleic Acids, 2003, 22, 2133-2144.

Seley, K. L.; Quirk, S.; Salim, S.; Zhang, L.; Hagos, A. 'Unexpected Inhibition of S-Adenosyl-L-homocysteine Hydrolase by a Guanosine Nucleoside' Bioorg. Med. Chem. Lett. 2003, 13, 1985-1988.

Seley, K. L.; Zhang, L.; Hagos, A.; Quirk, S. ''Fleximers'. Design and Synthesis of A New Class of Novel Shape-Modified Nucleosides' J. Org. Chem., 2002, 67, 3365-3373.

Seley, K. L.; Zhang, L. Hagos, A. ''Fleximers'. Design and Synthesis of Two Novel Split Nucleosides' Org. Letters, 2001, 3, 3209-3210.

Barnard, D. L.; Stowell, V. D.; Seley, K. L.; Hegde, V. R.; Das, S. R.; Rajappan, V. P.; Schneller, S. W.; Smee, D. F.; Sidwell, R. W. 'Inhibition of Measles Virus Replication by 5'-Nor Carbocyclic Adenosine Analogues' Antiviral Chem. Chemoth.  2001, 12, 241-250.

Seley, K. L.; Januszczyk, P.; Hagos, A.; Zhang, L.; Dransfield, D.T. 'Synthesis and Antitumor Activity of Thieno-Separated Tricyclic Purines' J. Med. Chem., 2000, 43, 4877-4883.

Barnard, D. L.; Stowell, V. D.; Seley, K. L.; Hegde, V. R.; Das, S. R.; Rajappan, V. P.; Schneller, S. W. and Sidwell, R. W. 'Inhibition of Measles Virus Replication by 5'-Nor Carbocyclic Nucleoside Analogs' Antiviral Res. 2000, 46, 102.

Hegde, V. R.; Seley, K. L.; Schneller, S. W. Carbocyclic 5'-Norcytidine (5'-Norcarbodine)' J. Heterocycl. Chem. 2000, 37, 1361-1362.

Hegde, V. R.; Seley, K. L.; Schneller, S. W. 'Carbocyclic 5'-Noruridine' Nucleosides Nucleotides  2000, 19, 269-273.

Hegde, V. R.; Seley, K. L.; Chen, X.; Schneller, S. W. 'The Synthesis of Carbocyclic 5'-Nor Thymidine and an Isomer as Oligonucleotide Monomers' Nucleosides Nucleotides, 1999, 18, 1905-1910.

Seley, K. L.; Schneller, S. W. '7-Deaza-5'-noraristeromycin Derivatives Resembling L-Toyocomycin and L-Sangivamycin' J. Heterocycl. Chem.  1999, 36, 287-288.

Hegde, V. R.; Seley, K. L.; Schneller, S. W.; Elder, T. J. J. '5'-Amino-5'-deoxy-5'-noraristeromycin and Related Analogues' J. Org. Chem. 1998, 63, 7092-7094.

Seley, K. L.; Schneller, S. W. Korba, B. 'Does the Anti-HBV Activity of (+)-5'-Noraristeromycin Exist in its 4'-Epimer and 4'-Deoxygenated Derivatives?' J. Med. Chem.  1998, 41, 2168-2170.

Seley, K. L.; Schneller, S. W.; Korba, B.; de Clercq, E.; Rattendi, D.; Lane, S.; Bacchi, C. J. 'The Importance of the 4'-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5'-Noraristeromycin' Bioorg. Med. Chem. 1998, 6, 797-802.

Wu, J.; Schneller, S. W.; Seley, K. L.; de Clercq, E. 'Carbocyclic 7-Deazaguanine Oxetanocin Analogues' Heterocycles  1998, 47, 757-765.

Wu, J.; Schneller, S. W.; Seley, K. L.; Snoeck, R.; Andrei, G.; Balzarini, J.; de Clercq, E. 'Carbocyclic Oxetanocins Lacking the C-3' Methylene' J. Med. Chem. 1997, 40, 1401-1406.

Seley, K. L.; Schneller, S. W. Korba, B. 'A 5'-Noraristeromycin Enantiomer with Activity Towards Hepatitis B Virus' Nucleosides Nucleotides 1997, 16, 2095-2099.

Seley, K. L.; Schneller, S. W.; de Clercq, E. 'A Methylated Derivative of 5'-Noraristeromycin' J. Org. Chem.  1997, 62, 5645-5646.

Seley, K. L.; Schneller, S. W.; Rattendi, D.; Lane, S.; Bacchi, C. J. 'Synthesis and Anti-Trypanosomal Activity of a Series of 7-Deaza-5'-noraristeromycin Derivatives Varied in the Cyclopentyl Ring' Antimicrob. Agents Chemother.  1997, 41, 1658-1661.

Seley, K. L.; Schneller, S. W.; Rattendi, D.; Lane, S.; Bacchi, C. J. 'Synthesis and Anti-trypanosomal Activity of Various 8-Aza-7-deaza-5'-noraristeromycin Derivatives' J. Med. Chem.  1997, 40, 625-629.

Seley, K. L.; Schneller, S. W.; Rattendi, D.; Bacchi, C. J. '(+)-7-Deaza-5'-noraristeromycin as an Anti-Trypanosomal Agent' J. Med. Chem.  1997, 40, 622-624.

Seley, K. L.; Mosley, S. L. 'Purine Analogues and Their Role in Methylation and Cancer Chemotherapy' in DNA Methylation and Cancer Therapy, Moshe Szyf, Ed. Landes Bioscience,  Georgetown, TX, 2004, Chapter 13, pp 178-186.

Seley, K. L. 'Tricyclic Nucleosides Revisited' in Recent Advances in Nucleosides: Chemistry and Chemotherapy, pg. 299-326, C.K. Chu, Ed. Elsevier Science, 2002

Schneller, S. W.; Seley, K. L.; Hegde, V. R.; Rajappan, V. P. '5'-Norcarbanucleosides in L-Like Configurations' in Recent Advances in Nucleosides: Chemistry and Chemotherapy, pg. 291-297; C.K. Chu, Ed. Elsevier Science, 2002.

Seley, K. L. 'CoFactor' IDrugs, 2001, 4, 99-101.

Seley, K. L. 'Tezacitabine' Current Opin. Investigational Drugs   2000, 1, 135-140.

Seley, K. L. 'MDL 101,731' Investigational Drugs, Current Drugs Ltd, 1997.