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Office: MEYR 549B
Phone: 410-455-2521
Professional Interests
Research Group
Dale Whalen
Professor Emeritus
Post-Doctoral UCLA 1967; Ph.D. University of California at Berkeley 1965; B.S. Loras College 1961

Doan, L.; Whalen, D. L. 'Effects of Conformation of the Stereochemistry of Solvent Attack on Benzylic β-Hydroxycarbocations: Mechanisms of Epoxide Hydrolysis Reactions,' J. Org. Chem. 2006, 71, 7252-7260.

Zhao, C.; Whalen, D. L. 'Transition State Effects in the Acid-Catalyzed Hydrolysis of 5-Methoxyacenaphthalene 1,2-Oxide: Implications for the Mechanism of Acid-Catalyzed Hydrolysis of Cyclopenta[cd]pyrene 3,4-Oxide,' Chem. Res. Toxicol. 2006, 19, 217-222.

Whalen, D. L. 'Mechanisms of Hydrolysis and Rearrangements of Epoxides,' Adv. Phys. Org. Chem. 2005, 40, 247-298.

Ukachukwu, V. C.; Mohan, R. S.; Whalen, D. L. 'Kinetic Deuterium Isotope Effects on the Reactions of 2-(4-Methoxyphenyl)oxirane in Water Solutions,' ARKIVOC 2005 (iii), 45-58.

Doan, L.; Yagi, H.; Jerina, D. M.; Whalen, D. L. 'Synthesis and Hydrolysis of a cis-Chlorohydrin Derived from a Benzo[a]pyrene 7,8-Diol 9,10-Epoxide,' J. Org. Chem. 2004, 69, 8012-8017.

Sampson, K.; Paik, A.; Duvall, B.; Whalen, D. L. 'Transition State Effects in Acid-Catalyzed Aryl Epoxide Hydrolyses,' J. Org. Chem. 2004, 69, 5204-5211.

Doan, L.; Yagi, H.; Jerina, D. M.; Whalen, D. L. 'Chloride Ion Catalyzed Conformational Inversion of Carbocation Intermediates in the Hydrolysis of a Benzo[a]pyrene 7,8-Diol 9,10-Epoxide,' J. Am. Chem. Soc. 2002, 124, 14382-14387.

Bartas-Yacoubou, J.-M.; Maduike, N. Kyere, S.; Doan, L.; Whalen, D. L. 'Aryl Epoxide-Halohydrin Transformations: Stereochemistry of Reactions of Aryl Epoxides with Lithium Halide-Acetic Acid Reagent,' Tetrahedron Lett. 2002, 43, 3781-3782.

Doan, L.; Lin, B.; Yagi, H.; Jerina, D. M.; Whalen, D. L. 'New Insights on the Mechanisms of Reaction of Benzo[a]pyrene 7,8-Diol 9,10-Epoxides,' J. Am. Chem. Soc. 2001, 123, 6785-6791.

Whalen, D.; Doan, L.; Poulose, B.; Friedman, S.; Gold, A.; Sangaiah, R.; Ramesha, A.; Sayer, J.; Jerina, D. M. 'Mechanisms of Solution Reactions of Cyclopenta[cd]pyrene Oxide and Acenaphthylene Oxide,' Polycyclic Aromat. Hydrocarbons 2000, 21, 43-52.

Kalsi, A.; Kavarana, J.; Lu, T.; Whalen, D. L.; Hamilton, D. S.; Creighton, D. J. 'Role of Hydrophobic Interactions in Binding S-(N-Aryl/Alkyl-N-hydroxycarbamoyl)glutathiones to the Active Site of the Antitumor Target Enzyme Glyoxalase I,' J. Med. Chem. 2000, 43, 3981-3986.

Mohan, R. S.; Gavardinas, K.; Kyere, S.; Whalen, D. L. 'Spontaneous Hydrolysis Reactions of cis- and trans-β-Methyl-4-methoxystyrene Oxides (Anethole Oxides): Buildup of trans-Anethole Oxide as an Intermediate in the Spontaneous Reaction of cis-Anethole Oxide,' J. Org. Chem. 2000, 65, 1407-1413.