Research in this department covers basic questions
that include how the immune response in mammals is regulated,
how the maturation of retroviruses occurs, and what is the role
of metal ions in the etiology of Alzheimer’s disease. In
addition, research with direct clinical applications is being
carried out such as the development of anticancer agents and the
design of inhibitors of retroviral maturation. A wide range of
techniques is applied by a number of groups to study the structure
and function of proteins, carbohydrates, and nucleic acids. These
studies utilize technologically sophisticated techniques such
as NMR spectroscopy, electron paramagnetic resonance spectroscopy,
electrospray mass spectrometry, and X-ray crystallography, to
more traditional organic chemistry and physical chemistry approaches.
Bush, C. Allen
Biosynthesis and structures of glycoprotein oligosaccharides and bacterial antigenic polysaccharides.
Fabris, Daniele
Investigation of protein-nucleic acids, metal-nucleic acids, and small ligand-nucleic acids interactions.
Fishbein, James
The biochemical mechanism of the induction of chemoprotective enzymes is studied in various cultured cells type with a view toward elucidating important metabolites and their chemical reactivity.
Garcin, Elsa
Protein Chemistry
Garvie, Colin
Structure/function studies of proteins involved in gene regulation.
Hosmane, Ramachandra
Biochemical investigations of novel heterocycles, nucleosides and nucleotides as potential substrates and/or inhibitors of enzymes of nucleic acid metabolism.
Karpel, Richard
Single-stranded DNA- and RNA-binding proteins: Kinetics and control of binding, and relationship of these properties to the regulation of DNA replication, repair and recombination.
Lu, Wuyuan
Chemical protein synthesis; Structure and function relationships for proteins in innate and adaptive immunity; Molecular design of antiviral and antitumor peptides.
Pollack, Ralph
Enzyme Reaction Mechanisms
Szalai, Veronika
Structural and functional roles of transition metal ions in biology, including diseases like Alzheimer's.
Wang, Lai-Xi
Glycobiology; Immunology; structure and function of glycoproteins
