Research in this department covers basic questions
that include how the immune response in mammals is regulated,
how the maturation of retroviruses occurs, and what is the role
of metal ions in the etiology of Alzheimer’s disease. In
addition, research with direct clinical applications is being
carried out such as the development of anticancer agents and the
design of inhibitors of retroviral maturation. A wide range of
techniques is applied by a number of groups to study the structure
and function of proteins, carbohydrates, and nucleic acids. These
studies utilize technologically sophisticated techniques such
as NMR spectroscopy, electron paramagnetic resonance spectroscopy,
electrospray mass spectrometry, and X-ray crystallography, to
more traditional organic chemistry and physical chemistry approaches.
My lab uses biomolecules and molecular biology techniques in order to synthesize inorganic materials for Li ion battery and catalysis applications.
Understanding spatial and temporal regulation of cellular metabolic enzymes and their organization in cells
Bush, C. Allen
Biosynthesis and structures of glycoprotein oligosaccharides and bacterial antigenic polysaccharides.
The biochemical mechanism of the induction of chemoprotective enzymes is studied in various cultured cells type with a view toward elucidating important metabolites and their chemical reactivity.
Single-stranded DNA- and RNA-binding proteins: Kinetics and control of binding, and relationship of these properties to the regulation of DNA replication, repair and recombination.
Chemical protein engineering; Structure and function relationships for proteins in innate and adaptive immunity; Molecular design of antiviral and antitumor peptides.
Glycobiology; Immunology; structure and function of glycoproteins
Understanding the mechanism and role of cell communication via the release of gliotransmitters.