Development of new agents with potential for beneficial
impact on human health is an area of significant interest in the
Department. This entails both chemical synthesis and also studies
seeking to understand the molecular basis of the intended or known
pharmacological action. Specific projects cover a broad spectrum
of interests. These include; the construction and study of agents
with potent anti-viral, anti-biotic or anti-cancer properties;
synthesis of signal cascade disruptors/enhancers; development
of artificial blood; study of structure-activity relations and
enzyme mechanism and inhibition; as well as understanding general
mechanisms of drug action and the molecular basis of cancer chemoprevention.
Fishbein, James
Delineating the mechanistic basis by which cancer chemoprotective compounds manifest their activity with a view toward improving efficacy.
Hosmane, Ramachandra
Synthesis and biochemical/biological evaluation of novel heterocycles, nucleosides and nucleotides as potential antiviral and anticancer agents.
Seley-Radtke, Katherine
Discovery, design and synthesis of enzyme inhibitors for use as medicinal agents with chemotherapeutic emphasis in the areas of anticancer, antiviral, and antiparasitic targets.
