A topical discussion of the science of chemistry and its relationship to our everyday lives. While no previous knowledge of chemistry is required, this course does involve the use of chemical formulas and such basic math as algebra and scientific notation. Note: This course is intended for non-science majors and cannot be used as a prerequisite to other chemistry courses.

An introduction to chemistry for science majors and other students who require a thorough grounding in the principles of chemistry. Topics treated include the atomic-molecular theory of matter, stoichiometry, states of matter, chemical nomenclature, energetics of chemical and physical processes, solutions, periodic properties, VSEPR, molecular orbital theory and chemistry of familiar elements. Note: Credit may not be obtained for both CHEM 101 and 123. Prerequisite: Working knowledge of elementary algebra. Highly recommended: MATH 150.

Principles of chemical and physical equilibrium, liquids and solids, elementary thermodynamics, electron and proton transfer reactions, electrochemistry, chemical kinetics and a further study of the periodic properties of the elements. Prerequisite: CHEM 101..

Companion course to CHEM 102, intended for all students who require two or more years of chemistry. Prerequisite: CHEM 101. Pre- or corequisite: CHEM 102.

A two-semester chemistry course intended for students preparing for health sciences. Topics include atomic-molecular theory, properties of the elements, bonding and molecular structure, solutions, elementary organic chemistry, proteins, lipids, carbohydrates and nucleic acids. Note: CHEM 123-124 cannot be used as prerequisite to other chemistry courses. This course will fulfill requirements in chemistry for students in the nursing, dental hygiene and physical therapy programs and may be of interest to certain other students. Credit may not be obtained for both CHEM 101 and 123. A working knowledge of elementary algebra is required. (Fall)

Continuation of CHEM 123 Note: Credit may not be obtained for both CHEM 102 and 124. (Spring) Prerequisite: CHEM 123.

A companion course to CHEM 124. This course, together with CHEM 123 and 124, will complete the one year of chemistry required by nurses, dental hygienists, physical therapists and others in health-related sciences, except premed and predental. (Spring) Prerequisite: CHEM 123. Pre- or corequisite: CHEM 124.

This course cannot be applied to the requirements of the major in chemistry. It does, however, provide a mechanism whereby a student intending to pursue a career in chemistry may acquire academic credit for training obtained while employed outside of the university. The number of credits assigned, which may not exceed three per semester, is based upon the instructor’s assessment of the scientific level of the employment and its contribution to the professional development of the student. The grade assigned is based upon a report written by the student and the instructor’s appraisal of the student’s performance. Note: This course is offered on a P/F basis only. Prerequisite: Consent of supervising faculty.

A lecture-laboratory course covering the theory and practice of quantitative chemical analysis. The emphasis is on homogeneous and heterogeneous equibilibria involved in gravimetric and volumetric methods. Introduction to instrumental techniques includes potentiometry, spectrophotometry and chromatographic separations. (Spring and Fall) Prerequisite: CHEM 102 and 102L.

Laws of thermodynamics, with emphasis on their application to chemical systems. Topics considered include thermochemistry, equations of state, physical and chemical equilibrium, and electrochemistry. (Fall) Prerequisite: CHEM 102 and MATH 152. Pre- or corequisite: PHYS 122.

Continuation of CHEM 301. Molecular structure and bonding, interpretation of spectra, introductory quantum and statistical mechanics, kinetic theory of gases, chemical kinetics and the theory of rate processes. (Spring) Prerequisite: CHEM 301.

This course is designed to familiarize students with the qualitative and quantitative concepts of physical chemistry as they apply to biochemical systems and macromolecules. Approximately one-third of the course will be devoted each to topics in thermodynamics, kinetics and spectroscopy. Topics will include: general equilibrium thermodynamics emphasizing biochemical applications: ligand binding, biological oxidation-reduction reactions, membranes, colligative properties, and transport properties; kinetics, including elementary rate laws, reaction mechanisms and activated processes, and relaxation and enzyme kinetics; and introduction to quantum chemistry, electronic structure and bonding, and molecular spectroscopy (including vibrational, electronic and magnetic spectroscopy). The use of modern instrumentation will be discussed throughout the course. Prerequisites: CHEM 102, 351, and MATH 152. Pre- or corequisites: PHYS 112 or 122 or permission of instructor.

Laboratory exercises encompassing experimental problems in physical, inorganic, synthetic and instrumental analytical chemistry. Emphasis is placed on the analysis of data, the techniques of measurement and computer- interfaced instrumentation. (Fall) Pre- or corequisite: CHEM 301.

Continuation of CHEM 311L. (Spring) Prerequisite: CHEM 311L and/or 302.

The chemistry of aliphatic and aromatic compounds, including bonding, stereochemistry and reactions of functional groups. Reaction mechanisms, synthetic methods and characterization of organic molecules. Prerequisite: CHEM 101 and 102.

Companion course to CHEM 351. Prerequisite: CHEM 101, 102 and 102L. Pre-or corequisite: CHEM 351.

Continuation of CHEM 351. (Spring) Prerequisite: CHEM 101, 102 and 351.

Continuation of CHEM 351L. (Spring) Prerequisite: CHEM 101, 102, 102L, 351 and 351L. Pre- or corequisite: CHEM 352.

Individuals involved in contemporary scientific research have ethical responsibilities for their conduct. The goal of this course is to provide students considering a career in scientific research with an appropriate framework for establishing appropriate scientific integrity. Various topics relevant to scientific integrity, including defining, handling and responding to fraud and misconduct; peer review; obligations and rights of students and mentors; ethical conduct in animal and human experimentation; ownership of data; reagents; and intellectual property, authorship and conflict of interest will be presented and discussed. Specific research situations and examples of past ethical violations will be used to illustrate appropriate ethical standards. Note: Permission of course coordinator is required.

In this course, the problem of lead poisoning will serve as a focal point to develop perspective, insight and retrospection into an important societal problem. The course will be presented as a series of seminars that cover in-depth the many facets of lead and lead poisoning. Some of the topics include the chemistry of lead, its history, toxicology, ecology, legal and political ramifications, and its remediation. The culmination of the course will be the student projects, which will meld their knowledge, interpretation of lecture material and personal experience.

Independent study supervised by a faculty member. The course is intended for students who wish to study topics in chemistry not covered by the regular course offerings. One credit hour is equal to a minimum of four hours of work in the laboratory per week. Note: This course offered on a P/F basis only. Prerequisite: Consent of supervising faculty

The course skills that will be emphasized in the course are anaerobic synthesis and advanced characterization methods. These methods will be applied to inorganic complexes important in biological/medicinal inorganic chemistry and nanomaterials. This interdisciplinary course aims to combine traditional inorganic chemistry concepts/methods with areas of inorganic chemistry not covered in lower-level courses. Prerequisite: CHEM 300 & CHEM 352L; Co-requisite: CHEM 405

Intended for senior-level undergraduates and graduate students, this course focuses on the role and function of metals in biology. Topics include metalloenzyme mechanisms, spectroscopy and use of metals in medicine. (Spring) Prerequisite: CHEM 405 or CHEM 437 and permission of instructor.

The course is designed to help develop an appreciation and understanding of how to write a computer program to solve problems related to chemical research. Fundamentals of electronic chemical structure calculations. This is not a theory course, but a practical course in which programming techniques, data handling and online comput-ational tools are discussed. Prerequisite: CHEM 302 or 303 and permission of the instructor.

An advanced treatment of the chemistry of proteins and protein-containing supramolecular structures. The topics include isolation and purification of proteins, structure of proteins and relation of structure to biological function. (Spring) Prerequisite: BIOL 430, CHEM 437 or equivalent.

The topics presented would not normally be covered in any other biochemistry course and may include an advanced treatment of enzyme kinetics with emphasis upon two-substrate systems, allosteric control mechanisms, replication and transcription, and the biochemistryof specialized tissues. Prerequisite: CHEM 437 and 438.

A survey of nucleic acid structure and function, with emphasis on chemical aspects. Topics will include DNA and RNA structure, packaging of nucleic acids, chemical and physical properties of nucleic acids, proteins and enzymes of DNA replication, fidelity of nucleic acid synthesis, biochemistry of DNA recombination, enzymology of transcription and RNA processing. Prerequisite: CHEM 437 or equivalent, or permission of instructor.

Structure and function of the carbohydrates of glycoprotiens, glycolipids, proteoglycans and bacterial polysaccharides; carbohydrates as informational macromolecules; decoding by lectins; biosynthesis; structure; engineering of glycoproteins; bacterial adhesion; and virulence and tumor antigens Prerequisite: CHEM 437

The first semester of a two-semester sequence providing a thorough introduction to the principles of modern biochemistry. Major topics include enzyme kinetics and the structures and properties of proteins, nucleic acids, carbohydrates and lipids. (Fall) Prerequisite: BIOL 100 and CHEM 352 or equivalent.

Modern methods of biochemical research. Laboratory experiments are designed to provide experience in working with biologically active materials and familiarity with standard biochemical techniques. These include spectrophotometry; chromatography; isotope tracer techniques; ultra-centrifugation; enzyme kinetics; and isolation, purification and characterization of proteins, nucleic acids and subcellular organelles. Two laboratory sessions per week. Prerequisite: CHEM 352L. Corequisite: CHEM 437 and consent of the instructor.

Continuation of CHEM 437. Includes metabolic pathways and selected topics in nucleic acid and membrane chemistry. (Spring) Prerequisite: CHEM 437 or equivalent.

Introduction to the physical chemistry of macromolecules. Emphasis is placed on the development of broad general concepts applicable to the study of synthetic and biological macromolecules. Topics considered include determination of molecular weight and molecular weight distributions; conformational properties of high polymers; and thermodynamics and transport properties of polymer solutions, polyelectrolytes and polymerization processes. Techniques such as sediment-ation analysis, light scattering, osmometry and viscometry are discussed. (Fall) Prerequisite: CHEM 301.

Structural determination of proteins and nucleic acids in the solid state and in solution. Transitions between and stability of secondary and tertiary structure. Ligand binding and association processes. Interpretation of spectra, titration curves and multicomponent equilibria, hydrodynamic properties and fluorescence polarization. (Spring) Prerequisites: CHEM 301, or 303 and 437.

Team-taught course covering theory and applications of advanced spectroscopic techniques used to study the structure and function of biomacromolecules (polysaccharides, DNA, coenzymes and cofactors). Aspects of modern Fourier Transform NMR, including one- and two-dimensional methods (COSY, NOESY, TOCSY) will be presented. Principles of mass spectrometry and examples of the potential, limitations and applications of electron impact; desorption ionization; high-resolution tandem-mass spectrometry and interfaced chromatography-mass spectro-metry will be discussed. Theory and applications of other spectroscopic techniques, including molecular vibrational (raman, resonance raman and infrared), electron spin resonance (ESR) and laser fluorescence spectroscopies also will be presented. Prerequisite: CHEM 301 and permission of instructor(s).

Survey of theoretical methods for simulation of biopolymer conformation. Energy maps, energy minimization and molecular dynamics simulation. Influence of solvents. Applications to proteins, nucleic acids, etc. Calculations using the CHARMm code. Prerequisites: CHEM 301, or 303 and 437.

An in-depth survey of the properties, reactions and synthesis of heterocyclic compounds containing the heteroatoms of oxygen, sulfur and/or nitrogen. The course will consist of lectures based on readings from monographs and current literature. Prerequisite: CHEM 352.

Advanced general treatment of the study of organic reaction mechanisms, with emphasis on the development of broad principles governing various organic reactions. Description of metastable intermediates such as carbonium ions, carbanions, carbenes and free radicals, kinetic effects in relation to structure, conformational analysis and stereochemistry. (Fall) Prerequisite: CHEM 352.

Introduction to theoretical aspects of organic chemistry. Molecular orbital approximations, linear-free energy relationships, general theory of acid-base catalysis, medium effects and isotope effects. (Spring) Prerequisite: CHEM 301 or 303. Recommended: CHEM 451.

A survey of organic chemical principles governing structure, properties and reactions of nucleic acids, including synthesis of nucleic acid bases, nucleosides, nucleotides and polynucleotides, and their important synthetic analogs possessing antiviral and antitumor properties. Study of reactivity of nucleic acid building blocks, including addition and substitution reaction, ring-openings and rearrangements, hydrolysis of glycosidic and phosphodiester bonds, and photochemical reactions. Study of primary structure, acid-base property, tautomerism and conformation of nucleic acids. Review of secondary structure, base-pairing and -stacking interactions, helical structure, stability, conformation, denaturation, renaturation and cross-linking. Prerequisite: CHEM 352

A survey of principles and methods of drug design, including modern rational approach aided by computers, disease models, natural products, analogue synthesis, and pharmacophore identification; physicochemical principles of drug action, including solubility, partition coefficients, surface interactions, stereochemical, electronic and quantum chemical factors, chemical bonding and quantitative structure-activity relationships (QSAR); receptor concept of drug action, including nature, definition, characterization, models and classical theories of receptor function; mechanisms of drug action, including enzyme stimulation, inhibition and regulation; drug distribution, metabolism and inactivation, including bioavailability, biotransform-ations, chemical and metabolic stability, pharmacokinetic variability and design of prodrugs; case studies selected from a list of antitumor, analgetic, antimicrobial, anticholinergic, antiadrenergic, psychoactive and cardiovascular drugs; and current status of and future impact on drug development, including protein therapeutics, gene therapy, antisense drugs, cytokines and drug resistance. Prerequisite: BIOL 100 and CHEM 352.

The course will cover the total syntheses of selected natural products from animal, plant, marine, bacterial and fungal sources, including vitamins, alkaloids, hormones, terpenoids and antibiotics. Both historically significant total syntheses of landmark, such as those of cholesterol, morphine, strychnine and vitamin B12, as well as the more modern total syntheses, such as those as taxol, bleomycin and enediyne antibiotics, will be elaborated. Students who opt to take the course for graduate credits (CHEM 657) will be required to write an additional term paper and/or make an oral presentation on the total synthesis of a selected natural product. Prerequisite: CHEM 352 or equivalent.

A lecture-laboratory course covering the theory, instrumentation and applications of modern instrumental techniques. Advantages and limitations of different instrumental methods are discussed using selected topics of environmental, pharmacological and toxicological analysis. Laboratory experiments include polarography and pulse voltammetry, anodic stripping analysis, potentiometry with ion-selective electrodes, flame and electrothermal atomic absorption, UV-VIS spectro-photometry, capillary gas chromatography, and high-performance liquid chromato-graphy (HPLC) (Spring) Prerequisite: CHEM 300 and 311L or equivalent, or consent of instructor.

Primary mass spectrometric methods for the structural characterization and functional investigation of biomolecules, such as proteins, nucleic acids, carbohydrates, etc. will be covered. Sequencing, identification of post-translational modifications, proteome application and functional investigations of biomolecules will be discussed using a problem-based approach. Prerequisites: CHEM 300 and 301.

The relationship between the chemical properties of toxic chemicals, e.g. chlorinated hydrocarbons, metals, drugs, solvents and naturally occurring toxicants and their genotoxic effects, are systematically examined. Topics covered include biotransformations, dose-response and statistical considerations, chemical air pollution, pharmacokinetics, chemical mutagenicity and carcinogenicity, analytical procedures, geo-chemistry of environmental pollution, radiation toxicology and combinations of chemicals. Prerequisite: BIOL 430 or equivalent or consent of instructor.

The mechanism of enzyme action will be examined with emphasis on three-dimensional structure of enzymes, chemical catalysis, methods of determining enzyme mechanisms, stereochemistry of enzymatic reactions, detection of intermediates, affinity labels and suicide inhibitors, transition state analogs, energy relationships, evolutionarily ?perfect? enzymes, genetic engineering and enzymes, and use of binding energy in catalysis. Instruction will be in both lecture and seminar format, with emphasis on recent literature. Prerequisite: CHEM 352 and 437. Recommended: CHEM 451.

This course is intended for senior science students. Both format and topics may vary. Note: The course may be repeated for credit. Prerequisite: Permission of the instructor.

Original laboratory or theoretical investigation suitable for advanced students. Registration with the consent of the faculty member with whom the research is to be carried out. Hours to be arranged. One credit hour is equal to a minimum of four hours work in the laboratory per week. A formal paper will be required on research performed. Note: This course offered on a P/F basis only. Prerequisite: Consent of supervising faculty member. This course may be repeated for credit, subject to the following provision: a maximum of six credits of CHEM 499 or a maximum of eight credits from the combination of BIOL 398, 399, 499, CHEM 399 and 499 may be applied toward the 120 credits for graduation.