Dr Charles Eggleton
Assistant Professor
Mechanical Engineering
University of Maryland Baltimore County
1000 Hilltop Circle Baltimore, MD 21250
Office: Engineering 205
Phone: (410) 455-3334
Fax: (410) 455-1052
Email: eggleton@umbc.edu
Website: www.umbc.edu/bfml
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Academic Preparation
B.S., Naval Architecture, University of California, Berkeley, 1986
M.S., Aeronautics and Astronautics, Stanford University, 1989
Ph.D., Aeronautics and Astronautics, Stanford University, 1994 |
Employment History
Assistant Professor, Department of Mechanical Engineering, University of Maryland, Baltimore County, 1998
Post Doctoral Fellow, The Johns Hopkins University, Baltimore, MD, 1994-1997
Naval Architect, Shell Development Company, Bellaire, TX, Summer 1986 and '87
David Taylor Naval Ship Research Center, Bethesda, MD, Summer 1985 Student Assistant |
Research Areas
In my work, I use state-of-the-art numerical approaches to understand the response of highly deformable fluid particles with complex interfaces to applied flows.
In one case, the fluid particle is the cell, and the complexity of the interface arises from the constitutive behavior of the cell membrane and its linkages to the cytoskeleton and the nucleus. This is a particularly rich system, as the biochemical response of the cell depends on its mechanical history. My aim is to use these models to understand this coupled response to improve control over biochemical processes. Thus far I have used a continuum description for the membrane that can be related to bilayer and cytoskeletal mechanics. My vision for my future work is to introduce a molecular scale to these computations, that is, to include a discrete component model that more accurately describes the cytoskeleton and its linkages to the nucleus and cell membrane, and that can be linked to changes in biochemistry.
In the other case, the fluid particles are drops and bubbles with surfactant-laden interfaces. The mechanical response of these interfaces is also strongly nonlinear and history dependent. Non- deforming fluid interfaces can be tangentially mobile, or can present no-slip surfaces. Deforming interfaces also have a range of constitutive responses which have been delineated in my work. By understanding the mechanical response of surfactant-laden drops to applied flows in terms of the kinetic and thermodynamic parameters that describe the surfactants, paradigms to use surfactants to create desired drop break up modes can be developed.
Visit Research Pages
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Courses Taught at UMBC ME
ENME 320, Introduction to Fluid Mechanics
ENME 432L, Fluids/Energy Lab
ENME 640, Fundamentals of Fluid Mechanics
ENME 645, Applied Computational Thermo/Fluids |
Selected Publications
Davidson, K. M., Shrinivasan, S., Eggleton, C. D. Martin, M. R., Using computational Fluid Dynamics to estimate circulation time distributions in Bioreactors, Biotechnology Progress, vol. 19, 1480-1486, (2003).
Mascari, L., Ymele-Leki, P., Eggleton, C. D., Speziale, P., Ross, J. M., Fluid Shear Contributions to Bacteria Cell Detachment Initiated by a Monoclonal Antibody, Biotechnology and Bioengineering, vol. 83, no. 1, 65-74, (2003).
Eggleton, C.D., Tsai, T.M., Stebe, K.J., Tip streaming from a drop in an extensional flow in the presence of surfactants, Physical Review Letters, vol. 87, no. 4, (2001)
Eggleton, C.D., Pawar, Y.P., Stebe, K.J., Insoluble surfactants on a drop in an extensional flow: a generalization of the stagnated surface limit to deforming interfaces. Journal of Fluid Mechanics, vol. 385, 79-99, (1999)
Eggleton, C.D., Popel, A.S., Large Deformation of red blood cell ghosts in a simple shear flow. Physics of Fluids, vol. 10, no. 8, 1834-1845, (1998)
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