Total joint replacements (TJR) remains one of the most successful treatments for arthritis. The most common materials used for artificial joints are metals such as cobalt-chrome alloys or titanium alloys, which articulates against ultra-high molecular weight polyethylene (UHMWPE). The wear of metals used for artificial total knee arthroplasty (TKA) can be reduced with the use of micro-textured carbide surfaces. Micro-textured carbide surfaces are deposited on a CoCrMo alloy using microwave plasma-assisted chemical vapor deposition (MPCVD). Wear tests were conducted to determine the wear mechanism, properties of the micro-textured surfaces and the influence of lubrication for seven different wear couple systems. These seven wear couple systems were (1) CoCrMo-on-UHMWPE (control 1), (2) CoCrMo-on-CoCrMo (control 2), (3) CoCrMo-on-Carbide, (4) Carbide-on-CoCrMo, (5) Carbide-on-UHM WPE, (6) Carbide-on-Carbide_2h deposition, and (7) Carbide-on-Carbide4h deposition. The research presented in this thesis addresses the following: (I) explore and analyze rheolgoical behavior of bovine calf serum (BCS) with and without antibacterial agent and compare the properties of synovial fluid relevant to testing artificial joints, (2) determine the tribological (wear) behavior of the “brain coral” system, and (3) examine and characterize the mechanical and material properties of the micro-textured CoCrMo alloy surface that are relevant to wear performance. Rheological testing was conducted to determine the dynamic viscosity and viscoelastic properties of the bovine calf serum (BCS), the lubricant used to conduct the wear studies. The rheological studies showed that the viscosity of bovine calf serum (BCS) increases with an increase in concentration with and without antibacterial agent before and after the serum was used for wear testing.