Chemical and Biochemical Engineering (CENG)


Department of Chemical and Biochemical Engineering

JULIA ROSS, Chair
DOUGLAS FREY, Graduate Program Director

Professors
FREY, DOUGLAS, Ph.D., University of California, Berkeley; Chromatography of biopolymers, downstream bioprocessing
GOOD, THERESA, Ph.D., University of Wisconsin, Madison; Cellular engineering, protein aggregation and disease, biomedical engineering
MARTEN, MARK R., Ph.D., Purdue University; Microbial proteomics, morphology, atomic force microscopy and bioprocessing
MOREIRA, ANTONIO R., Ph.D., University of Pennsylvania; Regulatory/GMP issues, scale changes, fermentation and cell culture, product comparability, process analytical technology
RAO, GOVIND, Ph.D., Drexel University; Fluorescence-based sensors and instrumentation, high throughput bioprocessing, fermentation and cell culture
ROSS, JULIA, Ph.D., Rice University; Cell and tissue engineering, cell adhesion in microbial infection, thrombosis

Professor of the Practice
BALES, TARYN, Ph.D., University of Pittsburgh; Undergraduate education and outreach, transport phenomena

Assistant Professors
CASTELLANOS, MARIAJOSÉ, Ph.D., Cornell University; Biocomplexity, systems biology
LEACH, JENNIE, Ph.D., University of Texas, Austin; Biomaterials and tissue engineering
GARCIN,ELSA, Ph.D.

Research Associate Professors
KOSTOV, YORDAN, Ph.D., Bulgarian Academy of Sciences; Low-cost optical sensors, instrumentation development, biomaterials
TOLOSA, LEAH, Ph.D., University of Connecticut, Storrs; Fluorescense based sensors, protein engineering, biomedical diagnostics, molecular switches

Research Assistant Professors
GE, XUDONG, Ph.D., UMBC; Sensor matrix development, dialysis based sensor

Degrees Offered

M.S. (thesis and non-thesis), Ph.D
Post-Baccalaureate Certificate in Biochemical Regulatory Engineering

Program Description

An individual plan of graduate study in chemical engineering compatible with the student’s interest and background is offered. The primary emphasis of the program’s research activities is biotechnology and biomedical engineering. Cross-discipline thesis research projects in these areas are encouraged.

Program Specialties

The admission requirements and procedures correspond to the requirements set forth by the UMBC Graduate School. Opportunities are available for undergraduate students to enroll in the B.S./M.S. program in their senior year. For students with non-chemical engineering B.S. degrees wishing to enter the M.S. or Ph.D. program, a series of courses at the undergraduate level are required prior to beginning graduate courses in Chemical Engineering. In general, those classes can be taken during the student’s first year in graduate school.

Degree Requirements

For the M.S. in Chemical Engineering, a minimum of 30 credit hours of coursework in technical areas relating directly to chemical engineering are required. Up to nine credit hours of advanced upper-level undergraduate courses may count toward this minimum. M.S. thesis degree candidates are required to pass an oral qualifying examination, perform a minimum of six credit hours of thesis research and pass a final thesis defense.

Ph.D. in Chemical Engineering

The Ph.D. is awarded only upon sufficient evidence of high attainment in scholarship and the demonstrated ability to engage in independent research in the field of chemical engineering. It is not awarded for the completion of course and seminar requirements, no matter how successfully completed. A minimum of 27 credit hours of courses numbered 600 or higher, approved by the program, are required. Appropriate courses taken while earning the M.S. degree from the program may be used to partially fulfill this requirement.

A maximum of six credit hours of ENCH 648, Special Problems may be used in fulfilling this requirement. In addition to the 27 hours of course work, a minimum of 12 credit hours of ENCH 898 or ENCH 899, Doctoral Dissertation Research are required. Courses taken to fulfill the requirements of the program must be approved in advance by the chemical engineering graduate program director and by the student’s advisor, if one has been selected. All Ph.D. candidates are required to take five required graduate course covering topics in advanced mathematics, biochemistry, kinetics, thermodynamics and transport phenomena. Students are required to pass written and oral qualifying examinations. The examinations are given annually, and the student has two opportunities to pass each exam. Additional requirements are imposed by the Graduate School.

Post-Baccalaureate Certificate in Biochemical regulatory engineering

This graduate certificate includes completion of 12 credits by taking the sequence of four courses ENCH 660, ENCH 662, ENCH 664 and ENCH 666. The certifcate provides a comprehensive exposure to the issues related to obtaining and maintaining regulatory agency approval (such as, from the Food and Drug Administration) for biopharmaceutical products.

Facilities and Special Resources

The program’s research facilities include state-of-the-art laboratories at the Technology Research Center and the $26 million Engineering Building. These facilities are extensively equipped with modern fermentation, cell culture, chromatography, microscopy, proteomics and other bioanalytical equipment. Microcomputers provide the capabilities for data acquisition, analysis, modeling, simulation and control within these facilities.

Financial Assistance

Graduate teaching and research assistantships are available to highly qualified candidates through the program.

COURSE LISTING

ENCH 437L
Chemical Engineering Laboratory [3]
Application of chemical engineering process and unit operation principles in small-scale, semi-commercial equipment. Data from experimental observations are used to evaluate performance and efficiency of operations. Emphasis is placed on correct presentation of results in report form. Prerequisite: ENCH 427 and ENCH 440.

ENCH 440
Chemical Engineering Kinetics [3]
Fundamentals of chemical reaction kinetics and their application to the design and operation of chemical reactors. Reaction rate theory, homogeneous reactions in batch and flow systems, heterogeneous reactions and catalysis, biochemical reactions and catalytic reactor design. Prerequisite: ENCH 300, ENCH 427 and CHEM 301.

ENCH 444
Process Engineering Economics and Design I [3]
Principles of chemical engineering economics and process design. Emphasis on equipment types, equipment design principles, capitalcost estimation, operating costs and profitability. Simulation languages such as Super Pro and Aspen Plus are used for detailed design projects. Prerequisite: ENCH 427 and ENCH 440.

ENCH 445
Equilibrium-Stage Computations [3]
Solution thermodynamics, phase equilibria, characteristics of separation processes, simple and multi-stage equilibrium processes, binary and multi-component separation processes and computational approaches. Pre- or corequisite: ENCH 427.

ENCH 446
Process Engineering Economics and Design II [3]
Application of chemical engineering principles for the design of chemical processing equipment. Typical problems in the design of chemical and bioprocess plants. Simulation languages such as Super Pro and Aspen Plus are used for detailed design projects. Note: Comprehensive reports are required. Prerequisite: ENCH 444.

ENCH 468
Research [1-3]
Investigation of a research project under the direction of a faculty member. Note: Comprehensive reports are required. Prerequisite: Consent of instructor.

ENCH 485L
Biochemical Engineering Laboratory [3]
Techniques of measuring pertinent parameters in fermentation reactors, quantification of production variables for primary and secondary metabolites such as enzymes and antibiotics, the insolubilization of enzymes for reactors, and the demonstration of separation techniques such as ultrafiltration and affinity chromatography.Prerequisite: ENCH 482.

ENCH 609
Graduate Seminar [1]

ENCH 610
Chemical Engineering Thermodynamics [3]
Advanced application of the general thermodynamic methods to chemical engineering problems. First- and second-law consequences, estimation and correlation of thermodynamic properties, phase and chemical reaction equilibria.

ENCH 630
Transport Phenomena [3]
Heat, mass and momentum transfer theory from the viewpoint of the basic transport equations. Steady and unsteady state, laminar and turbulent flow, boundary layer theory and mechanics of turbulent transport, with specific application to complex chemical engineering situations.

ENCH 640
Advanced Chemical Reaction Kinetics [3]
The theory and application of chemical reaction kinetics to reactor design. Reaction rate theory, homogeneous batch and flow reactors, fundamentals of catalysis, microbial growth kinetics and enzyme kinetics.

ENCH 642
Chemical Engineering Systems Analysis [3]
Dynamic response applied to process systems. Goal and modes of control, LaPlace transformations, analysis and synthesis of simple control systems, closed-loop response and dynamic testing. Prerequisite: ENCH 300, ENCH 425 and MATH 325. Corequisite: ENCH 427 and ENCH 440.

ENCH 648
Special Problems in Chemical Engineering [1-6]

ENCH 650
Chemical Process Development [3]
Chemical process industries from the standpoint of technology, raw materials, products and processing equipment. Operations of major chemical processes and industries combined with quantitative analysis of process requirements and yields. Prerequisite: ENCH 427, ENCH 440.

ENCH 652
Advanced Chemical Engineering Analysis [3]
Application of digital computers to chemical engineering problems. Numerical methods, programming, differential equations and curve fitting. Prerequisite: ENCH 427 and ENCH 440.

ENCH 654
Chemical Process Analysis and Optimization [3]
Applications of mathematical models to the analysis and optimization of chemical processes. Models based on transport, chemical kinetics and other chemical engineering principles will be employed. Emphasis on evaluation of process alternatives. Prerequisite: ENCH 440 and ENCH 427.

ENCH 659
Statistical Design of Experiments [3]
This course introduces the basic concepts which underlie modern statistically designed experimental programs. The methods taught in this course allow the experimenter to discriminate between real effects (those caused by changes in controlled variables) and experimental error in systems which are inherently noisy. Statistically designed experimental programs typically test many variables simultaneously, and are very efficient tools for developing empirical mathematical models which accurately describe physical and chemical processes. They are readily applied to production plant, pilot plant and laboratory systems, and should be a part of every practicing engineer’s repertoire. At the end of this course, the student will be able to select an appropriate experimental design for the problem at hand, to set up, conduct and analyze the results of statistically designed experiments, and to understand the statistical basis for these techniques. Prerequisite: ENCH 427 and ENCH 440.

ENCH 660
Regulatory Issues in Biotechnology [3]
Provides a comprehensive coverage of all steps involved with the regulatory approval process for a biotechnology-derived product. Documentation preparation for IND, NDA, BLA. Pre-clinical safety data, clinical studies, facilities inspection and scientific and regulatory principles.

ENCH 662
Good Manufacturing Practices for Bioprocesses [3]
In-depth coverage of the development and implementation of good manufacturing practices (GMPs) in the biotech industry. Topics include building and facilities, equipment design, utilities, in-process controls, records and adequate process validation.

ENCH 664
Quality Control and Quality Assurance for Biotechnology Products [3]
In-depth coverage of the key issues associated with adequate quality-control systems, assays and stability for novel biotechnology products: quality concepts, product release testing and specifications, in-process testing, product characterization, qualityassurance documentation and audits and vendor certification.

ENCH 666
Biotechnology GMP Facility Design, Construction and Validation [3]
Presents an in-depth discussion of the engineering design of a biotech facility under GMP compliance. Topics covered include bulk plant design, process equipment design, utilities, instrumentation, controls and computerization, facility and software validation.

ENCH 682
Biochemical Engineering [3]
Introduction to biochemical and microbiological applications for commercial and engineering processes, including industrial fermentation, enzymology, ultrafiltration, food and pharmaceutical processing and resulting waste treatment. Enzyme kinetics, cell growth, energetics and mass transfer. Prerequisite: ENCH 427 and ENCH 440.

ENCH 686
A Survey of Sensors and Instrumentation [3]
This course will provide a broad overview of sensors and instrumentation used in a number of applications. Starting with basic definitions, the course will move on to various principles (physical, chemical and biological) used to sense a variety of parameters. A simple sensor will be constructed during the course to provide hands-on experience in sensor design.

ENCH 693
Introduction to Biomedical Engineering [3]
Application of engineering analysis to biomedical issues including drug delivery, biomaterials, tissue engineering receptor mediated processes, cardiovascular mechanics, physiological mass transfer and biomedical device design. Prerequisite: ENCH 427 and ENCH 440.

ENCH 720
Process Analysis and Simulation [3]
Development of mathematical models of chemical processes based on transport phenomena, chemical kinetics and other chemical engineering methods. Emphasis on principles of model building and simulation using mathematical solutions and computer methods. Prerequisite: ENCH 630.

ENCH 730
Bioseparations [3]
Introduction to biotechnology separation problems: physico-chemical properties of biomolecules, characterization of biological fluids and bioseparation processes, cell disruption, membrane processes, centrifugation, chromatography, precipitation and crystallization and protein folding/refolding.

ENCH 735
Chemical Process Dynamics [3]
Analysis of open and closed control loops and their elements, dynamic response of processes, choice of variables and linkages, dynamic testing and synthesis, noise and drift, chemical process systems analysis and strategies for optimum operation. Prerequisite: Differential equations or consent of instructor.

ENCH 737
Chemical Process Optimization [3]
Techniques of modern optimization theory as applied to chemical engineering problems. Optimization of single- and multi-variable systems with or without constraints. Application of partial optimization techniques to complex chemical engineering processes.

ENCH 761
Enzyme Engineering [3]
Enzyme science and kinetics: principles of enzyme insolubilization and denaturation with application to design, operation and modeling of enzyme reactors. The relationship between mass transfer and apparent kinetics in enzyme systems and techniques of separation and purification of enzymes. Prerequisite: ENCH 640.

ENCH 762
Advanced Biochemical Engineering [3]
Advanced topics to include use of a digital computer for mathematical modeling of the dynamics of biological systems; separation techniques for heat-sensitive, biologically active materials; and transport phenomena in biological systems. Prerequisite: ENCH 682 or consent of instructor.

ENCH 764
Bio-Energetics [3]
Analysis of energetic processes based on elements of thermodynamics and kinetics. A background in biochemistry, thermodynamics and physical chemistry is desirable. Topics will be covered briefly by instructor, followed by in-depth discussion and student-led presentations. Note:This is an advanced graduate-level course.

ENCH 766
Tissue Engineering [3]
Applications of the principles of chemical engineering and biological science to the understanding and production of tissue systems of biomedical interest. Prerequisite: Consent of instructor.

ENCH 768
Protein Engineering [3]
The basic elements of how proteins are produced, modified and characterized. Prerequisite: ENCH 482, basic biochemistry or consent of instructor.

ENCH 772
Advanced Biochemical Engineering: Upstream Processes [3]
Upstream bioprocesses engineering will be discussed from both an academic and industrial perspective. Topics covered will include bioreactor theory and operation, mixing and hydrodynamics, fermentation broth rheology, mathematical modeling of cell systems and metabolic engineering. Prerequisite: ENCH 482 or consent of instructor.

ENCH 799
Master’s Thesis Research [1-6]
Master’s thesis research under the direction of a faculty member. Note: Six credit hours are required for the M.A.

ENCH 818
Advanced Topics in Thermodynamics [3]
Advanced topics in thermodynamics of interest to the instructor and students are covered. Possible topics include statistical thermodynamics, solution theory, highpressure phenomena, non-equilibrium thermodynamics and complex reaction equilibria. Prerequisite: ENCH 610 or consent of instructor.

ENCH 828
Advanced Topics in Chemical Reaction Systems [3]
Design and analysis of complex industrial reactors. Catalytic reactions, polymerizations and biochemical reactions. Modeling and dynamics of continuous processes, reactor optimization and physico-chemical phenomena in multi-component heterogeneous reaction systems. Prerequisite: ENCH 640 or consent of instructor.

ENCH 838
Advanced Topics in Transfer Theory [3]
Selected topics are covered. Possible topics include turbulence, mixing, multi-phase flow, non-Newtonian phenomena and mass transfer. Prerequisite: ENCH 630 or consent of instructor.

ENCH 848
Advanced Topics in Separation Processes [3]
Industrial importance of separation processes. Physical principles for separation, liquid/ liquid separations versus distillation, extractive distillation, absorption stripper systems, membrane separations, ultracentrifugation, electrophoresis, large-scale chromatography, molecular sieves and pressure swing adsorption, synthesis of alternative separation schemes, trade-off and optimization. Prerequisite: Consent of instructor.

ENCH 898
Pre-Candidacy Doctoral Research [3-9]
Research on the doctoral dissertation conducted under the direction of a faculty advisor before candidacy.

ENCH 899
Doctoral Dissertation Research [9]
Research on the doctoral dissertation under direction of faculty advisor. Note: A minimum of 18 credit hours are required for the Ph.D degree.