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UMBC High Performance Computing Facility
Please note that this page is under construction. We are documenting the 240-node cluster maya that will be available in Spring 2014. Currently, the cluster tara is still available. Please see the 2013 Resources Pages under the Resources tab.
Molecular modeling of effects of phosphorylation on proteins
Dr. Lasse Lindahl, Faculty, Biology
Dr. Ian Thorpe, Faculty, Chemistry
Dr. Bruce Johnson, Faculty, Chemistry
Nusrat Rahman, Grad Student, Biology

Post-translational modifications, like phosphorylation, acetylation, affects a proteins charge, hydrophobicity, which results in changes in the protein's conformation, binding properties etc. The project will use molecular simulation tools (eg. Gromacs) to simulate effect of phosphorylation of ribosomal protein L5 on its binding to 5S rRNA.