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| S-N-Hydroxy N-Methyl Carbamoyl Glutathione [glycyl]-0- |
| This invention is a novel chemotherapeutic approach to cancer treatment |
| that is based on a metabolic pathway that is dramatically different between |
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| cancer cells and normal cells has been proposed. The method involves |
| inducing higher steady-state concentrations of cytotoxic methylglyoxal by |
| inhibiting the enzymes that catalyze the conversion of methylglyoxal to D- |
| Glutathione N-Hydroxycarbamoyl Thioesters and Method of Inhibiting |
| Collagen and Flexible Polymer Drug Delivery Device |
| This invention is a highly concentrated solution of negatively charged |
| collagen molecules and a negatively charged flexible polymer at neutral pH. |
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| The principle feature of this invention is that the combination or mixture of |
| rigid-rod collagen and flexible coil polymers gives unique benefits in |
| controlling the release of protein drugs. |
| Rigid polymers, such as collagen, tend to reduce diffusion rates more |
| effectively than flexible polymers when mesh sizes are similar, while flexible |
| polymers, which have much smaller mesh sizes, can fill mesh spaces more |
| effectively than rigid polymers when they are concentrated. |
| Drug Delivery Device and Method for Employing the Same |
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