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Lynanne McGuire, Ph.D.
Assistant Professor
Degree: Ph.D. 1999 Binghamton University, Clinical Psychology,
Binghamton, New York
Area: Clinical Psychology, Behavioral Medicine
Office: MP 339 x(410)-455-3952
Lab: SS 513 x(410)-455-4536
Fax: (410)-455-1055
E-mail: lmcguire@umbc.edu
Website: to be added in the future
Research Interests
Dr. McGuire is a clinical health psychologist with specialization
in psychoneuroimmunology and pain-related behavioral medicine. She
examines the influence of psychosocial characteristics, aging, and
pain on health through the key pathways of stress-related hormones
(neuroendocrine function) and immune function. The projects described
below are conducted in collaboration with colleagues at Johns Hopkins
School of Medicine (Drs. Haythornthwaite, Edwards, Page, and Wigley)
and the University of Maryland, Baltimore (Dr. Magaziner and colleagues).
Pain is the most common presenting medical complaint, and a
significant contributor to poor quality of life, morbidity, and
mortality. A potential pathway between pain and morbidity or mortality
involves pain-related changes in neuroendocrine and immune function.
One line of research in Dr. McGuire's laboratory involves the controlled
examination of the time course of pain's effects on neuroendocrine
and immune changes, pain parameters (e.g., duration, intensity)
necessary or sufficient for producing such changes, and psychosocial
variables (e.g., negative emotions, catastrophizing) that might
mediate the association between pain, neuroendocrine, and immune
function. Dr. McGuire is also examining how age may modify these
relationships. The longer term goal of this program of research
is to test the impact of psychological interventions in modifying
pain-related health outcomes. This line of work includes community
volunteers of a wide age range, and clinical patients who experience
acute pain (e.g, surgery patients) and chronic pain (e.g., arthritis
patients).
Dr. McGuire's second line of research involves patients with
systemic sclerosis (scleroderma; SSc), a rare connective tissue
disease that can include severe dysfunction of the skin, musculoskeletal
system, kidneys, lungs, heart, and gastrointestinal tract. Scleroderma
can involve several painful symptoms, yet pain in SSc has received
little attention. Dr. McGuire's current research focuses on pain
and healing of finger lesions in these patients. Delayed healing
of wounds places chronically ill patients at risk for negative outcomes,
including distress, disability, and amputations. Although finger
lesions in SSc patients are reported to be painful and a source
of distress and disability, few studies have specifically examined
finger lesion pain and healing. Dr. McGuire and colleagues are evaluating
the relationships among psychosocial factors, pain, immune changes,
and subsequent healing of naturally occurring finger lesions in
patients with SSc. Data in this study are collected using patient
prospective daily recording in electronic diaries and digital photography.
In addition to informing the treatment of SSc patients, knowledge
of contributing factors in delayed wound healing can inform interventions
in other populations in which slowed healing of wounds is particularly
problematic (e.g., in diabetes mellitus) and can lead, in extreme
cases, to amputations.
A third area of investigation involves psychosocial factors
and immune changes relevant to morbidity and mortality outcomes
following hip fracture in older adult women. Hip fracture in older
adults is a major health problem. It is estimated that as many as
a third of hip fracture patients die within a year of their fracture,
and of those who do survive 40% fail to return to prefracture level
of function. The goal of this work is to identify psychosocial and
immune characteristics that may place women at risk for poorer health
outcomes postfracture. This research is done in collaboration with
Dr. Magaziner and colleagues at UMB Department of Epidemiology,
Division of Gerontology and focuses on data obtained in the Baltimore
Hip Studies.
Selected Publications
McGuire, L., Kiecolt-Glaser, J. K., & Glaser, R. (2002).
Depressive symptoms and
lymphocyte proliferation in older adults. Journal of Abnormal
Psychology, 111, 192-197.
Kiecolt-Glaser, J.K., McGuire, L.M., Robles, T., & Glaser,
R. (2002). Emotions,
morbidity, and mortality: New perspectives from psychoneuroimmunology.
Annual Review of Psychology, 53, 83-107.
Kiecolt-Glaser, J.K., McGuire, L.M., Robles, T., & Glaser,
R. (2002).
Psychoneuroimmunology: Psychological influences on immune function
and health. Journal of Consulting and Clinical Psychology,
70, 537-547.
Kiecolt-Glaser, J.K., McGuire, L., Robles, T., & Glaser,
R. (2002)
Psychoneuroimmunology and Psychosomatic Medicine: Back to the future.
Psychosomatic Medicine, 64, 15-28.
Robinson-Whelen, S., Tada, Y., MacCallum, R.C., McGuire, L.,
& Kiecolt-Glaser, J.K.
(2001). Long-term caregiving: What happens when it ends? Journal
of Abnormal Psychology, 110, 573-584.
Hadjiconstantinou, M., McGuire, L., Duchemin, A., Laskowski,
B., Kiecolt-Glaser, J.
K., & Glaser, R. (2001). Changes in plasma nerve growth factor
levels in older adults associated with chronic stress. Journal
of Neuroimmunology, 116, 102-106.
Graduate Student Mentees
April Burns
Stacey Sandusky
Current Student Research Projects
Coming in the future.
Teaching
Health Psychology (Psyc 385)
Physiological Psychology (Psyc 335)
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