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About October 2013

This page contains all entries posted to Chemical and Biochemical Engineering News & Events in October 2013. They are listed from oldest to newest.

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October 2013 Archives

October 11, 2013

Seminar: Christopher Kistler (Merck), Oct. 21

Christopher Kistler, Associate Principle Scientist for Merck

Date: Monday, October 21
Time: 12:00pm - 1:00pm
Location: TRC 206
Title: Technology Improvements to Accelerate Process Development of Biologics

Christopher Kistler, Krista Alvin, Rachel Bareither, and David Pollard
Biologics New and Enabling Technologies, Merck & Co., Inc., 126 E. Lincoln Ave, Rahway, NJ

Pressures continue to reduce the time from discovery to product launch and minimize the costs of not only manufacturing but also process development. This is particularly difficult for upstream development where large DOE designs in lab scale reactors, provides a significant equipment and resource constraint. The presentation will show how innovation through automation and single-use technology has led to more efficient process development. This includes the creation of multi use tools to handle both cell culture and microbial expression platforms. Improvements will be shown for end to end development focusing on upstream processing followed by purification and analytics. Examples include the use of cell line development automation for the elimination of manual shakeflask stages and increase throughput of clonal evaluation. For more advanced process development a novel small scale single use prototype bioreactor is evaluated. This system is designed for automated multi tank experimentation with robotic sampling, feeding and control. This is integrated with high throughput purification and analytics using a systematic approach of statistical design of experiments in combination with 'omics' technologies. This allows for a rapid end to end process development and builds a fundamental understanding of the impact of process operations to control process consistency and product quality.

October 28, 2013

Dr. Upal Ghosh featured on Smithsonian Science website


A recent article on the Smithsonian Science website highlights the work of CBEE professor Upal Ghosh, along with Cynthia Gilmour from the Smithsonian Environmental Research Center, and their colleagues. These researchers have found a new low-cost, nonhazardous way to reduce the toxicity of hot spots polluted with mercury by using charcoal to trap it in the soil.

The complete Smithsonian Science article can be found at this link and the study "Activated Carbon Mitigates Mercury and Methylmercury Bioavailability in Contaminated Sediments," published in the journal Environmental Science & Technology, can be found here