CBEE Seminar with Dr. Corey Wilson (Yale University), Assistant Professor of Chemical & Environmental Engineering, Biomedical Engineering & Molecular Biophysics & Biochemistry
Date: Monday, September 29
Location: ITE 104
Title: Investigating Protein Structure-Function Relationships via Rational Design
Abstract: The overarching goal of the research conducted in the Wilson Research Group is to establish an integrated experimental and computational framework to translate our understanding of the fundamental principles of biophysics and biochemistry (i.e., the physicochemical properties that confer function) into useful processes, devices, therapies, and diagnostics that will benefit society. To accomplish this the Wilson Research Group focuses on two Protein Engineering approaches: (i) computational protein design and (ii) optimized strategies in protein evolution. This research program is an integrated multidisciplinary initiative that includes applied mathematics, computer science, physical chemistry, experimental protein chemistry, biochemistry, cell biology, and molecular biophysics. In turn, our ability to engineer biological materials is a rigorous test of our understanding of the structure-function relationship—on multiple time and length scales. Accordingly, this research platform holds the promise of expanding our general knowledge with regard to protein folding, molecular interactions, signal transduction and enzyme-catalyzed reactions.